Chromoanagenesis in Osteosarcoma [PDF]
BiomoleculesChromoanagenesis is a catastrophic genomic phenomenon involving sudden, extensive rearrangements within one or a few cell cycles. In osteosarcoma, the most prevalent malignant bone tumor in children and adolescents, these events dramatically alter the ...
Nan Wu, Victoria Stinnett, Ying S Zou
exaly +7 more sources
Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis [PDF]
G3: Genes, Genomes, Genetics, 2022 Chromoanagenesis is a catastrophic event that involves localized chromosomal shattering and reorganization. In this study, we report a case of chromoanagenesis resulting from defective meiosis in the MEIOTIC ASYNAPTIC MUTANT 1 (asy1Arabidopsis ...
Weier Guo, Luca Comai, Isabelle M Henry
doaj +8 more sources
Chromoanagenesis from radiation-induced genome damage in Populus. [PDF]
PLoS Genetics, 2021 Chromoanagenesis is a genomic catastrophe that results in chromosomal shattering and reassembly. These extreme single chromosome events were first identified in cancer, and have since been observed in other systems, but have so far only been formally ...
Weier Guo, Luca Comai, Isabelle M Henry
doaj +9 more sources
A Maternally Inherited Rare Case with Chromoanagenesis-Related Complex Chromosomal Rearrangements and De Novo Microdeletions [PDF]
Diagnostics, 2022 Chromoanagenesis is a phenomenon of highly complex rearrangements involving the massive genomic shattering and reconstitution of chromosomes that has had a great impact on cancer biology and congenital anomalies. Complex chromosomal rearrangements (CCRs)
Jui-Hung Yen +2 more
exaly +5 more sources
An Integrated Approach Including CRISPR/Cas9-Mediated Nanopore Sequencing, Mate Pair Sequencing, and Cytogenomic Methods to Characterize Complex Structural Rearrangements in Acute Myeloid Leukemia [PDF]
BiomedicinesComplex structural chromosome abnormalities such as chromoanagenesis have been reported in acute myeloid leukemia (AML). They are usually not well characterized by conventional genetic methods, and the characterization of chromoanagenesis structural ...
Michael Phan +9 more
doaj +3 more sources
Festuca pratensis-like Subgenome Reassembly from a “Chromosomal Cocktail” in the Intergeneric Festulolium (Poaceae) Hybrid: A Rare Chromoanagenesis Event in Grasses [PDF]
Plants, 2023 Festuca and Lolium grass species are used for Festulolium hybrid variety production where they display trait complementarities. However, at the genome level, they show antagonisms and a broad scale of rearrangements.
Izolda Pašakinskienė
doaj +4 more sources
Optical genome mapping improves detection and characterisation of cytogenetic abnormalities in non-Hodgkin lymphomas. [PDF]
Br J HaematolOptical genome mapping (OGM) is feasible on fresh and frozen tissue lymphoma samples and demonstrated its added value for accurate diagnostic classification. OGM surpasses karyotype and FISH in refining diagnoses of lymphoma, identifying class‐defining rearrangements along with prognostic markers.
Fall C +15 more
europepmc +2 more sources
Complex genomic rearrangements of the Y chromosome in a premature infant [PDF]
Molecular CytogeneticsBackground Chromoanagenesis is an umbrella term used to describe catastrophic “all at once” cellular events leading to the chaotic reconstruction of chromosomes. It is characterized by numerous rearrangements involving a small number of chromosomes/loci,
Stephanie A. Balow +6 more
doaj +2 more sources
Glycolytic Enzymes Are Part of an Oncogenic Network in AML [PDF]
CellsErythroid acute myeloid leukemia (AML) cell line OCI-M2 expresses a particular oncogenic network: IRF6, in concert with ETV2 and HEY1, aberrantly activates NKL homeobox gene NKX2-4, which in turn represses megakaryocytic lineage factor FLI1 ...
Stefan Nagel +2 more
doaj +2 more sources
Optical genome mapping as a high-resolution tool for uncovering cytogenetic complex and cryptic alterations in a cohort of patients with MDS and AML [PDF]
npj Precision OncologyCytogenetic and molecular studies are the standard of care in the diagnosis of myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML), which are characterized by a highly heterogeneous genetic landscape.
Neus Torres-Hernández +19 more
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