Results 31 to 40 of about 425 (140)
Unravelling a KMT2A::ARHGEF12 fusion within chromoanagenesis in acute myeloid leukemia using Optical Genome Mapping [PDF]
Annals of HematologyValerie Soenen +2 more
exaly +2 more sources
Multiple Chromoanasynthesis in a Rare Case of Sporadic Renal Leiomyosarcoma: A Case Report
Frontiers in Oncology, 2020 We present the genetic profile of kidney giant leiomyosarcoma characterized by sequencing of 409 cancer related genes and chromosomal microarray analysis.
Kirill Igorevich Anoshkin +12 more
doaj +1 more source
Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?
The Journal of Pathology: Clinical Research, 2021 Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. More than a third of patients do not respond to standard therapy and urgently require alternative treatment options.
Baptiste Ameline +6 more
doaj +1 more source
Does chromoanagenesis play a role in the origin of B chromosomes? [PDF]
Heredity (Edinb)Abstract B chromosomes (Bs) exist in addition to the standard (A) chromosomes in a wide range of species. The process underlying their origin is still unclear. We propose pathways of intra- and interspecific origin of B chromosomes based on known mechanisms of chromosome evolution and available knowledge of their sequence composition in ...
Houben A +5 more
europepmc +3 more sources
Molecular Cytogenetics, 2021 Background Mantle cell lymphoma (MCL) is derived from naïve CD5+ B-cells with the cytogenetic hallmark translocation 11;14. The presence of additional abnormalities is associated with blastoid variants in MCL (BMCL) and confers a poor prognosis.
Veronica Ortega +5 more
doaj +1 more source
The Journal of Pathology, Volume 260, Issue 5, Page 637-648, August 2023., 2023 Abstract Bone and soft tissue tumors are generally classified into complex karyotype sarcomas versus those with recurrent genetic alterations, often in the form of gene fusions. In this review, we provide an overview of important co‐occurring genomic alterations, organized by biological mechanisms and covering a spectrum of genomic alteration types ...
Josephine K Dermawan, Brian P Rubin
wiley +1 more source
Molecular Cytogenetics in the Era of Chromosomics and Cytogenomic Approaches
Frontiers in Genetics, 2021 Here the role of molecular cytogenetics in the context of yet available all other cytogenomic approaches is discussed. A short introduction how cytogenetics and molecular cytogenetics were established is followed by technical aspects of fluorescence in ...
Thomas Liehr
doaj +1 more source
Construction and evaluation of gRNA arrays for multiplex CRISPR‐Cas9
Yeast, Volume 40, Issue 1, Page 32-41, January 2023., 2023 Constructs to express guide RNAs (gRNAs) individually were assembled as BioBricks. The evaluation of single and multiplex CRISPR‐Cas9 gRNA systems was performed. Up to five successful simultaneous perturbations were achieved and assessed. Abstract Endonuclease system CRISPR‐Cas9 represents a powerful toolbox for the budding yeast's Saccharomyces ...
Gašper Žun +2 more
wiley +1 more source
Modern physiology vindicates Darwin's dream
Experimental Physiology, Volume 107, Issue 9, Page 1015-1028, 1 September 2022., 2022 New Findings What is the topic of this review? Revisiting the 2013 article ‘Physiology is rocking the foundations of evolutionary biology’. What advances does it highlight? The discovery that the genome is not isolated from the soma and the environment, and that there is no barrier preventing somatic characteristics being transmitted to the germline ...
Denis Noble
wiley +1 more source
Chromoanagenesis in plants and the effects of structural variation in poplar [PDF]
, 2023 Structural variation plays an important role in plant genome architecture and phenotypes. It is also suggested to be a new type of DNA marker for genomic selection in plant breeding.
Guo, Weier
core +1 more source