Pervasive chromosomal instability drives the karyotypic evolution of hypodiploid tumours [PDF]
Genome MedicineBackground Tumours frequently exhibit extreme levels of aneuploidy. While increases in ploidy are well-characterised, the opposite phenomenon—extensive chromosome loss leading to hypodiploidy—remains underexplored.
Elle Loughran +2 more
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Centromere diversity and its evolutionary impacts on plant karyotypes and plant reproduction. [PDF]
New PhytolSummary Karyotype changes are a formidable evolutionary force by directly impacting cross‐incompatibility, gene dosage, genetic linkage, chromosome segregation, and meiotic recombination landscape. These changes often arise spontaneously and are commonly detected within plant lineages, even between closely related accessions.
Steckenborn S, Marques A.
europepmc +2 more sources
The enrichment of breakpoints in late-replicating chromatin provides novel insights into chromoanagenesis mechanisms [PDF]
, 2020 The rise of pangenomic molecular assays allowed uncovering complex rearrangements named chromoanagenesis that were hypothesized to result from catastrophic shattering events.
Damien Sanlaville +46 more
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A molecular cytogenetic perspective on chromosome biology and crop improvement. [PDF]
Plant GenomeAbstract The age of molecular cytogenetic analysis of crop plants dawned in the late 1960s and early 1970s with new advances in the identification of somatic chromosomes by C‐banding and fluorescence in situ hybridization concurrent with advances in DNA cloning, sequencing, and mapping. In this perspective article dedicated to Ronald Phillips, I review
Gill BS.
europepmc +2 more sources
On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update [PDF]
Frontiers in Genetics, 2019 In the present review, we focus on the phenomenon of chromothripsis, a new type of complex chromosomal rearrangements. We discuss the challenges of chromothripsis detection and its distinction from other chromoanagenesis events.
Alla S. Koltsova +7 more
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Chromosome aberrations cause tumorigenesis through chromosomal rearrangements in a hepatocarcinogenesis rat model. [PDF]
Cancer SciThe pure chromosome aberration‐inducer acetamide caused hepatocarcinogenesis in a rat model through chromosomal rearrangements characterized by copy number alterations and structural alterations. The chromosomal rearrangements induced some specific oncogene amplifications in hepatic tumors.
Nakamura K +8 more
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Sorting by Multi-Cut Rearrangements
Algorithms, 2021 A multi-cut rearrangement of a string S is a string S′ obtained from S by an operation called k-cut rearrangement, that consists of (1) cutting S at a given number k of places in S, making S the concatenated string X1·X2·X3·…·Xk·Xk+1, where X1 and Xk+1 ...
Laurent Bulteau +3 more
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Constitutional Chromoanagenesis of Distal 13q in a Young Adult with Recurrent Strokes
Cytogenetic and Genome Research, 2016 Constitutional chromoanagenesis events, which include chromoanasynthesis and chromothripsis and result in highly complex rearrangements, have been reported for only a few individuals.
Speyer, D. +5 more
core +4 more sources
Translational Oncology, 2018 Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance.
Paulo Thiago de Souza-Santos +11 more
doaj +2 more sources
Sperm DNA Fragmentation as a Marker of Chromoanagenesis Occurrence During Spermatogenesis
International ...
Douet-Guilbert, Nathalie +9 more
core +4 more sources