Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer [PDF]
Frontiers in Oncology, 2013 The unique ability of centrosomes to nucleate and organize microtubules makes them unrivaled conductors of important interphase processes, such as intracellular payload traffic, cell polarity, cell locomotion, and organization of the immunologic synapse.
German A Pihan
exaly +9 more sources
Chromoanagenesis: a piece of the macroevolution scenario [PDF]
Molecular Cytogenetics, 2020 Over the last decade, new types of massive and complex chromosomal rearrangements based on the chaotic shattering and restructuring of chromosomes have been identified in cancer cells as well as in patients with congenital diseases and healthy ...
Franck Pellestor, Vincent Gatinois
doaj +6 more sources
Chromoanagenesis: cataclysms behind complex chromosomal rearrangements [PDF]
Molecular Cytogenetics, 2019 Background During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during ...
Franck Pellestor
doaj +5 more sources
Participation of retroelements in chromoanagenesis in cancer development [PDF]
Сибирский онкологический журналPurpose of the study: to determine the role of retroelements in chromoanagenesis mechanisms in cancer etiopathogenesis.Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems ...
R. N. Mustafin
doaj +3 more sources
Complex Chromosomal Rearrangements in B-Cell Lymphoma: Evidence of Chromoanagenesis? A Case Report [PDF]
Neoplasia: An International Journal for Oncology Research, 2016 Genomic instability is a well-known hallmark of cancer. Recent genome sequencing studies have led to the identification of novel phenomena called chromothripsis and chromoanasynthesis in which complex genomic rearrangements are thought to be derived from
Veronica Ortega +6 more
doaj +4 more sources
Chromoanagenesis Landscape in 10,000 TCGA Patients. [PDF]
Cancers (Basel), 2021 During the past decade, whole-genome sequencing of tumor biopsies and individuals with congenital disorders highlighted the phenomenon of chromoanagenesis, a single chaotic event of chromosomal rearrangement.
Rasnic R, Linial M.
europepmc +6 more sources
The Iceberg under Water:Unexplored Complexity of Chromoanagenesis in Congenital Disorders [PDF]
The American Journal of Human Genetics, 2019 Structural variation, composed of balanced and unbalanced genomic rearrangements, is an important contributor to human genetic diversity with prominent roles in somatic and congenital disease.
Zepeda-Mendoza, Cinthya J. +1 more
core +5 more sources
Stable transmission of an unbalanced chromosome 21 derived from chromoanasynthesis in a patient with a SYNGAP1 likely pathogenic variant [PDF]
Molecular Cytogenetics, 2018 Background Complex genomic structural variations, involving chromoanagenesis, have been implicated in multiple congenital anomalies and abnormal neurodevelopment.
Peter J. B. Sabatini +4 more
doaj +2 more sources
Generation of a Specific Fluorescence In Situ Hybridization Test for the Detection of Ovarian Carcinoma Cells [PDF]
BiomedicinesExaminations of ovarian cancer cells require the ability to identify tumor cells. Array-based comparative genome hybridization (aCGH) on 30 ovarian carcinomas (OC) identified three genomic loci (8q24.23; 17p12; 18q22.3) over- or under-represented in OC ...
Amelie Limburg +10 more
doaj +2 more sources
Mechanisms of structural chromosomal rearrangement formation [PDF]
Molecular Cytogenetics, 2022 Structural chromosomal rearrangements result from different mechanisms of formation, usually related to certain genomic architectural features that may lead to genetic instability.
Bruna Burssed +3 more
doaj +2 more sources