Results 61 to 70 of about 425 (140)
A framework for the clinical implementation of optical genome mapping in hematologic malignancies
American Journal of Hematology, Volume 99, Issue 4, Page 642-661, April 2024.Abstract Optical Genome Mapping (OGM) is rapidly emerging as an exciting cytogenomic technology both for research and clinical purposes. In the last 2 years alone, multiple studies have demonstrated that OGM not only matches the diagnostic scope of conventional standard of care cytogenomic clinical testing but it also adds significant new information ...
Brynn Levy +17 more
wiley +1 more source
, 2021 Chromoanagenesis is a descriptive term that encompasses classes of catastrophic mutagenic processes that generate localized and complex chromosome rearrangements in both somatic and germline genomes.
Jesper Eisfeldt (5007209) +9 more
core +1 more source
Simulating chromoanagenesis for tool development and testing
The human genome is large and complex. Variations in the genome of an organism can have drastic health implications from cancer to constitutional disease.
Jenkins, Kyle Leu
core +1 more source
Cell Reports: MethodsSummary: Although several recent studies have characterized structural variants (SVs) in germline and cancer genomes independently, the genomic contexts of these SVs have not been comprehensively compared. We examined similarities and differences between
Wolu Chukwu +11 more
doaj +1 more source
, 2021 Chromoanagenesis is a descriptive term that encompasses classes of catastrophic mutagenic processes that generate localized and complex chromosome rearrangements in both somatic and germline genomes.
Jesper Eisfeldt (5007209) +9 more
core +1 more source
, 2021 Apparently balanced chromosomal rearrangements (ABCRs) which include translocations, insertions, inversions, and complex rearrangements are rare events.
Masson, Julie
core +1 more source
, 2021 Les remaniements de structure chromosomique apparemment équilibrés (RCAE), qui comprennent les translocations, les insertions, les inversions et les remaniements complexes sont des évènements rares.
Masson, Julie
core
Exploring Chromosomal Instability and Chromoanagenesis as Engines of Genomic Evolution
Advances in sequencing techniques have revealed extreme chromosomal diversity andunderscored the importance of chromoanagenesis in macroevolution, speciation, and the contextof cancer and tumor progression. Evolution is essential for adapting to the environment, preparingfor future pressures, ensuring survival, and generating diversity. Here we discuss
Valentine Comaills +1 more
openaire +1 more source