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Chromogranin A and chromogranin B are sensitive circulating markers for phaeochromocytoma
European Journal of Endocrinology, 1997Abstract Specific assays for measurements of circulating chromogranin (Cg) A, CgB, CgC and pancreastatin (Ps) have recently been developed. The aim of the present study was to investigate the usefulness of these markers in diagnosing and following the effects of treatment of patients with phaeochromocytoma, and to compare the results with those
M, Stridsberg, E S, Husebye
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Chromogranin A and Chromogranin B in Noninvasive and Invasive Breast Carcinoma
Endocrine Pathology, 2002Recent progress in the study of chromogranins has revealed that there are many novel peptides derived from chromogranin with their multiple pathophysiologic roles. To learn the possible roles of chromogranin in breast carcinoma, we immunohistochemically investigated tissue localization of chromogranin A (CgA) and chromogranin B (CgB) in 10 normal ...
Noriko, Kimura +4 more
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NordiQC Assessments of Chromogranin A Immunoassays
Applied Immunohistochemistry & Molecular Morphology, 2019This paper is number 6 in a series developed through a partnership between ISIMM and Nordic IHC Quality Control with the purpose of reporting research assessing the performance characteristics of immunoassays in an external proficiency testing program.
Røge, Rasmus +4 more
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Chromogranin a as Biomarker in Diabetes
Biomarkers in Medicine, 2016Chromogranin A (CgA) is an established plasma marker of neuroendocrine tumors and has been suggested to also have a role as biomarker in other diseases. Whether CgA has any role as biomarker in diabetes is, however, unresolved, but its widespread distribution in the secretory granules in endocrine tissues including β cells and α cells in pancreas, and ...
Kasper, Broedbaek, Linda, Hilsted
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Chromogranin A: a multipurpose prohormone?
Acta Physiologica Scandinavica, 1994This minireview aims to discuss the new evidence for a multipurpose prohormone function for chromogranin A, the index member of the chromogranin/secretogranin family of universally distributed, uniquely acidic proteins.
K B, Helle, R H, Angeletti
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Human Pituitary Tumors Secrete Chromogranin-A*
The Journal of Clinical Endocrinology & Metabolism, 1989Chromogranin-A (CgA) has emerged as a serum and tissue marker for a number of endocrine tumors. We studied 15 patients with pituitary tumors to evaluate the clinical value of CgA as a serum and tissue marker for such tumors. One third of the patients had elevated serum CgA levels; 2 of these patients had nonsecreting pituitary tumors, and the other 3 ...
L J, Deftos +3 more
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Chromogranin A inhibits retinal dopamine release
Brain Research, 1993Chromogranin A (CGA), a peripherally active prohormone, is a soluble component in the secretory granules of many endocrine tissues and is cosecreted with their peptide or amine hormones. Using an antibody prepared against purified rat adrenal CGA, immunostaining was localized to the inner and outer plexiform layers of the rat retina and to selected ...
C J, Gibson, D G, Munoz
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Plasma Chromogranin-A in Primary Hyperparathyroidism*
The Journal of Clinical Endocrinology & Metabolism, 1989We sought an explanation for prior findings of high plasma chromogranin-A (Chr-A) in primary hyperparathyroidism. Chr-A was measured in plasma samples from 55 controls and 73 patients with primary hyperparathyroidism caused by adenoma (n = 14), sporadic or familial hyperplasia (n = 10), or familial multiple endocrine neoplasia type 1 (FMEN1; n = 49 ...
M S, Nanes, D T, O'Connor, S J, Marx
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Chromogranin A assay in clinical practice
Annales d'Endocrinologie, 2010Chromogranins belong to the family of secretory chromogranin and secretogranin proteins. They are found in secretory vesicles throughout the neuroendocrine system. Chromogranin A (CgA) is the main component. CgA acts as a prohormone submitted to processes of degradation through which active peptides are generated.
M, d'Herbomez +4 more
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WE‐14, a Chromogranin A‐Derived Neuropeptide
Annals of the New York Academy of Sciences, 2002Abstract: The neuropeptide WE‐14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE‐14 is generated in a distinct subpopulation of CgA‐immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands.
Curry, William +7 more
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