Results 171 to 180 of about 2,220 (203)

Neuropeptides and Chromogranins

Annals of the New York Academy of Sciences, 2002
Abstract: In large dense core vesicles, also referred to as chromaffin granules in adrenomedullary chromaffin cells, transmitters or hormones are stored together with neuropeptides and chromogranins. For most neuropeptides, functions have been established and new findings on their secretion, receptors, and synthesis regulation are reported.
Andrea, Laslop, Sushil K, Mahata
openaire   +2 more sources

Chromogranins: Current Concepts

2002
The large dense core secretory granules of adrenal medulla chromaffin cells synthesize, store and release catecholamines. Upon cell stimulation intragranular stored material is liberated into circulation to activate target organs. In addition to catecholamines, numerous peptides and proteins are present in chromaffin secretory granules and are ...
Dominique Aunis, Marie-Hélène Metz-Boutigue   +1 more
openaire   +1 more source

The Chromogranin–Secretogranin Family

New England Journal of Medicine, 2003
The members of the chromogranin–secretogranin family of peptide hormones, biogenic amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system and a variety of neurons. These granins, the chief of which is chromogranin A, participate in sympathoadrenal activity and serve as markers of neuroendocrine tumors, especially ...
Laurent, Taupenot, Kimberly L, Harper, Daniel T, O'Connor   +2 more
openaire   +2 more sources

Chromogranins in sympathetic nerves

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1971
In post-ganglionic sympathetic neurons, biochemical and electron-microscopical evidence indicate that noradrenaline is stored within granules which, although smaller, resemble adrenal medullary chromaffin granules in some respects. This resemblance between neuronal and adrenal medullary granules has been extended by immunological and enzymic ...
P, Banks, K B, Helle
openaire   +2 more sources

Chromogranin A

Current Opinion in Endocrinology, Diabetes & Obesity, 2016
The review summarizes the utility and limitations of chromogranin A (CgA) as a circulating biomarker for neuroendocrine tumors (NETs).Blood CgA measurement has numerous clinical limitations including poor assay reproducibility, low sensitivity (meta-analysis: 73%, 95% confidence interval: 0.71-0.76), and a paucity of prospective validation studies.
Mark, Kidd, Lisa, Bodei, Irvin M, Modlin
openaire   +2 more sources

Chromogranin A and chromogranin B are sensitive circulating markers for phaeochromocytoma

European Journal of Endocrinology, 1997
Abstract Specific assays for measurements of circulating chromogranin (Cg) A, CgB, CgC and pancreastatin (Ps) have recently been developed. The aim of the present study was to investigate the usefulness of these markers in diagnosing and following the effects of treatment of patients with phaeochromocytoma, and to compare the results with those
M, Stridsberg, E S, Husebye
openaire   +2 more sources

Chromogranin A and Chromogranin B in Noninvasive and Invasive Breast Carcinoma

Endocrine Pathology, 2002
Recent progress in the study of chromogranins has revealed that there are many novel peptides derived from chromogranin with their multiple pathophysiologic roles. To learn the possible roles of chromogranin in breast carcinoma, we immunohistochemically investigated tissue localization of chromogranin A (CgA) and chromogranin B (CgB) in 10 normal ...
Noriko, Kimura, Ryuichi, Yoshida, Shin-ichiro, Shiraishi, Monika, Pilichowska, Noriaki, Ohuchi   +4 more
openaire   +2 more sources

Proteolytic Processing of Chromogranins

2005
A number of peptides derived from the large chromogranin precursor proteins have been identified in neuroendocrine tissues and several of them have been attributed with functional data. In addition, various fragments were shown to be liberated by the action of prohormone convertases.
A, Laslop, A, Doblinger, U, Weiss
openaire   +2 more sources

Endothelial Handling of Chromogranin A

2005
The present study is the first to address the question of interaction between CGA and endothelial cells. It is evident that neither intact CGA nor N-terminal peptides activate endothelial cells by affecting the membrane potential. Nevertheless, bovine aorta endothelial cells (BAEC) bind and intemalise intact CGA in a temperature-dependent manner, and ...
MANDALA', Maurizio, STRIDSBERG M., HELLE K. B., SERCK HANSSEN G.   +3 more
openaire   +3 more sources

Measurements of chromogranin B can serve as a complement to chromogranin A

Regulatory Peptides, 2007
CgA has been shown to be an excellent marker for neuroendocrine tumours. However, there are two major drawbacks with CgA measurements; elevated levels are common in patients with decreased renal function and in patients on treatment with proton pump inhibitors. These problems are not seen with CgB measurements.
Mats, Stridsberg, Barbro, Eriksson, Bengt, Fellström, Gudjon, Kristiansson, Eva, Tiensuu Janson   +4 more
openaire   +2 more sources