Results 71 to 80 of about 1,274,518 (371)
Accurate chromosome segregation by probabilistic self-organization [PDF]
BMC Biology 2015 13:65, 2014 Background: For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-orientation). Incorrect attachments of kinetochore microtubules (kMTs) lead to chromosome mis-segregation and aneuploidy, which is often
arxiv +1 more source
Replication stress links structural and numerical cancer chromosomal instability
Nature, 2013 Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity. CIN is observed in most solid tumours and is associated with both poor prognosis and drug resistance ...
R. Burrell +20 more
semanticscholar +1 more source
Molecular Biology of the Cell, 2011 Recent advances in our understanding of chromosome behavior have been made possible by the development of cutting-edge cytological and molecular techniques. Presentations in this Minisymposium applied these techniques to a diverse set of topics. Sarah Elgin (Washington University) described her lab’s studies on the 1360 transposable element in ...
Lori L. Wallrath, David M. Gilbert
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Clinics and Practice, 2016 A 41-year old pregnant woman underwent amniocentesis to conduct a conventional karyotyping analysis; the analysis reported an abnormal karyotype: 46,XY,add(9)(p24). Chromosomal microarray analysis (CMA) is utilized in prenatal diagnoses.
Akiko Takashima +2 more
doaj +1 more source
Sperm and Oocyte Chromosomal Abnormalities
Biomolecules, 2023 Gametogenesis, the process of producing gametes, differs significantly between oocytes and sperm. Most oocytes have chromosomal aneuploidies, indicating that chromosomal aberrations in miscarried and newborn infants are of oocyte origin. Conversely, most
Osamu Samura +2 more
doaj +1 more source
AutoKary2022: A Large-Scale Densely Annotated Dataset for Chromosome Instance Segmentation [PDF]
arXiv, 2023 Automated chromosome instance segmentation from metaphase cell microscopic images is critical for the diagnosis of chromosomal disorders (i.e., karyotype analysis). However, it is still a challenging task due to lacking of densely annotated datasets and the complicated morphologies of chromosomes, e.g., dense distribution, arbitrary orientations, and ...
arxiv
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
Chromosomal abnormalities predisposing to infertility, testing, and management: a narrative review
Bulletin of the National Research Centre, 2021 Background Much interest has not been placed on the role of chromosomal abnormalities in the pathogenesis and rising prevalence of infertility in recent times.
Tajudeen O. Yahaya +6 more
doaj +1 more source