Results 21 to 30 of about 66,699 (303)

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells [PDF]

, 2010
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this ...
Valeri, Antonio, Beatriz Albella, Agirre, Xabier, Casado, José A., Pujol, MR, Rio, P, Bueren, Juan, Ariana Jacome, Albella Beatriz, Maria Eugenia Alonso-Ferrero, Juan A Bueren, Alonso-Ferrero, Maria Eugenia, Calasanz, M.J, María Roser Pujol, Hanenberg, H. (H.), Jacome Ariana, Alonso-Ferrero, ME, Hanenberg, H, Perez, L, Pérez-Fuentes, L. (Laura), Agirre, X, Jacome, A, Juan A. Bueren, Jacome, Ariana, Río Paula, Pujol María Roser, Surrallés Jordi, Prosper-Cardoso, F. (Felipe), Pérez Laura, Maria José Calasanz, Pujol i Calvet, M. Roser, Surralles, J. (Jordi), Hanenberg, Helmut, Prosper Felipe, Helmut Hanenberg, Pérez, Laura, Casado, J. (J.A.), Jacome, A. (Ariana), Albella, Beatriz, Bueren, JA, Hanenberg Helmut, Agirre Xabier, Bueren, J.A. (Juan A.), Valeri, A. (Antonio), Rio, P. (Paula), Calasanz-Abinzano, M.J. (Maria Jose), Prosper, F, José A Casado, Laura Pérez, Paula Río, Surrallés i Calonge, Jordi, Río, Paula, Antonio Valeri, Casado José A., Valeri Antonio, Jordi Surrallés, Casado, JA, Calasanz Maria José, Felipe Prosper, Surralles, J, José A. Casado, Calasanz, MJ, Albella, B, Albella, B. (B.), Alonso-Ferrero Maria Eugenia, Valeri, A, Alonso-Ferrero, M. (M.E.), Pujol, M.R. (María Roser), Bueren Juan A., Aguirre-Ena, X. (Xabier), Xabier Agirre, Prosper, Felipe   +71 more
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Evaluation of cytogenetic damage induced by antihypertensive drug Amlodipine: in vitro [PDF]

المجلة العراقية للصيدلة, 2022
Background: Amlodipine is a calcium channel blocker medication used to treat high blood pressure and coronary artery diseases for long term of use. Sufficient studies reporting the cytogenetic effects of this drug have not reporting yet.
Sayran Salih, Rawaa Abdo, Dian Salih, Asaad Alasady   +3 more
doaj   +1 more source

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes [PDF]

, 1988
Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter.
Cremer, Thomas, Manuelidis, L., Lichter, Peter, Borden, J., Ward, D. C.   +4 more
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Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis

Reproductive Biology and Endocrinology, 2020
Background Whether artificial oocyte activation (ICSI-AOA) will increase the risk of birth defects remains controversial. Thus, we performed this study to evaluate the risk of birth defects and further compare the incidence of different birth defects ...
Rui Long, Meng Wang, Qi Yu Yang, Shi Qiao Hu, Li Xia Zhu, Lei Jin   +5 more
doaj   +1 more source

Movement disorders associated with chromosomal aberrations diagnosed in adult patients [PDF]

, 2021
Introduction. Chromosomal aberrations are rare but important causes of various movement disorders. In cases of movement disorders associated with dysmorphic features, multiorgan involvement and/or intellectual disability, the identification of causative ...
Figura, Monika; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland, Różański, Dorota; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland, Koziorowski, Dariusz; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland, Smyk, Marta; Institute of Mother and Child, Department of Medical Genetics, Kasprzaka 17a, 01-211 Warsaw, Poland, Geremek, Maciej; Institute of Mother and Child, Department of Medical Genetics, Kasprzaka 17a, 01-211 Warsaw, Poland, Milanowski, Łukasz M.; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland; Mayo Clinic, Jacksonville, Florida, United States, Duszyńska-Wąs, Karolina; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland, Meisner-Kramarz, Izabela; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland, Szlufik, Stanisław; Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland   +8 more
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Frequency and Spectrum of Chromosomal Aberrations, Acrocentric Chromosome Associations Among Long Livers with Arterial Hypertension and Osteoarthritis Residing in the Carpathian Region

Galician Medical Journal, 2017
The frequency and spectrum of chromosomal aberrations, acrocentric chromosome associations among 264 long livers with arterial hypertension and osteoarthritis residing in the Carpathian region were analyzed.
Ruslan Kozoviy
doaj   +1 more source

Nonrandom chromosome abnormalities in cancer An overview [PDF]

, 2015
This chapter discusses neoplastic karyotypes. It emphasizes the difference between primary and secondary changes and address the questions of why, how, when, and where chromosome abnormalities arise; compare numerical and structural aberrations in terms ...
Mitelman, Felix,, Heim, Sverre,, Lund University.   +2 more
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Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia

Haematologica, 2010
Background Additional chromosomal aberrations in Philadelphia chromosome-positive chronic myeloid leukemia are non-random and strongly associated with disease progression, but their prognostic impact and effect on treatment response is not clear.
Theo D. Kim, Seval Türkmen, Michaela Schwarz, Gökben Koca, Hendrik Nogai, Christiane Bommer, Bernd Dörken, Peter Daniel, Philipp le Coutre   +8 more
doaj   +1 more source

The study of the impact of additional chromosomal aberrations and c-MYC and BCR::ABL1 genes amplification on CML patient’s characteristics: relation to haematological parameters and patient outcome

Egyptian Journal of Medical Human Genetics, 2023
Background Chronic myeloid leukaemia is characterised by genetic instability which results in additional cytogenetic aberrations that have been linked to progression to advanced phase.
Hend Attia, Dina Adel Fouad, Heba Samy
doaj   +1 more source

Chromosomal Aberrations in Squamous Cell Carcinoma and Solar Keratoses Revealed by Comparative Genomic Hybridization [PDF]

, 2003
Objective To identify chromosomal copy numbers of frequent genetic aberrations within squamous cell carcinomas (SCCs) and solar keratoses (SKs), and provide further evidence to support or challenge current dogma concerning the relationship between these
David J. Maguire, Weinstein, Stephen, Maguire, David, Lyn R. Griffiths, Griffiths, Lyn R., Kevin J. Ashton, Ashton, Kevin J., Griffiths, Lyn, Ashton, Kevin, Stephen R. Weinstein, Maguire, David J., Weinstein, Stephen R.   +11 more
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