Results 21 to 30 of about 946,819 (342)

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells

Archives of Toxicology, 2018
Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis extracts, as they prevent epilepsy, anxiety, and seizures.
C. Russo, F. Ferk, M. Mišík, Nathalie Ropek, A. Nersesyan, Doris Mejri, K. Holzmann, M. Lavorgna, M. Isidori, S. Knasmüller   +9 more
semanticscholar   +1 more source

Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq.

Cell Stem Cell, 2021
Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases.
G. Turchiano, G. Andrieux, Julia Klermund, Georges Blattner, V. Pennucci, Melina El Gaz, G. Monaco, Sushmita Poddar, Claudio Mussolino, T. Cornu, M. Boerries, T. Cathomen   +11 more
semanticscholar   +1 more source

Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.

Cell Stem Cell, 2010
Yoav Mayshar, U. Ben‐David, Neta Lavon, J. Biancotti, B. Yakir, A. Clark, K. Plath, W. Lowry, N. Benvenisty   +8 more
semanticscholar   +3 more sources

Chromosome breakpoint distribution of damage induced in peripheral blood lymphocytes by densely ionising radiation [PDF]

, 2006
Purpose: To assess the chromosomal breakpoint distribution in human peripheral blood lymphocytes (PBL) after exposure to a low dose of high linear energy transfer (LET) α-particles using the technique of multiplex fluorescence in situ hybridisation (m ...
Anderson, RM, Goodhead, DT, Papworth, DG, Sumption, ND   +3 more
core   +1 more source

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Nature Communications, 2021
Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC).
A. Iftekhar, Hilmar Berger, Nassim Bouznad, Julian Heuberger, F. Boccellato, U. Dobrindt, H. Hermeking, Michael Sigal, T. Meyer   +8 more
semanticscholar   +1 more source

Array comparative genomic hybridization and flow cytometry analysis of spontaneous abortions and mors in utero samples [PDF]

, 2009
Background: It is estimated that 10-15% of all clinically recognised pregnancies result in a spontaneous abortion or miscarriage. Previous studies have indicated that in up to 50% of first trimester miscarriages, chromosomal abnormalities can be ...
Björn Menten, Katrien Swerts, Barbara Delle Chiaie, Sandra Janssens, Karen Buysse, Jan Philippé, Frank Speleman, T Hassold, V Jobanputra, M Goddijn, KA Bell, B Lomax, J Menasha, DL Bruno, D Diego-Alvarez, D Diego-Alvarez, DN Azmanov, M Daniely, B Fritz, Y Hu, A Kallioniemi, AC Tabet, J Berezowsky, B Menten, D Pinkel, S Solinas-Toldo, B Menten, K Benirschke, M Benkhalifa, M Nagaishi, AJ Schaeffer   +30 more
core   +1 more source

Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization [PDF]

, 1990
Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes
Cremer, Christoph, Cremer, Thomas, Emmerich, Patricia, Lichter, Peter, Popp, Susanne   +4 more
core   +1 more source

Origin and clinical relevance of chromosomal aberrations other than the common trisomies detected by genome-wide NIPS: results of the TRIDENT study

Genetics in Medicine, 2017
PurposeNoninvasive prenatal screening (NIPS) using cell-free DNA in maternal blood is highly sensitive for detecting fetal trisomies 21, 18, and 13. Using a genome-wide approach, other chromosome anomalies can also be detected.
D. Van Opstal, M. V. van Maarle, K. Lichtenbelt, M. Weiss, Heleen G Schuring-Blom, S. Bhola, M. Hoffer, Karin Huijsdens–van Amsterdam, M. Macville, A. Kooper, B. Faas, L. Govaerts, Gita Tan-Sindhunata, N. D. den Hollander, I. Feenstra, R. Galjaard, D. Oepkes, S. Ghesquiere, R. Brouwer, L. Beulen, Sander Bollen, M. Elferink, R. Straver, L. Henneman, G. Page-Christiaens, E. Sistermans   +25 more
semanticscholar   +1 more source

Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis

Reproductive Biology and Endocrinology, 2020
Background Whether artificial oocyte activation (ICSI-AOA) will increase the risk of birth defects remains controversial. Thus, we performed this study to evaluate the risk of birth defects and further compare the incidence of different birth defects ...
Rui Long, Meng Wang, Qi Yu Yang, Shi Qiao Hu, Li Xia Zhu, Lei Jin   +5 more
doaj   +1 more source

Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.

Mutation research, 2017
Many antineoplastic drugs used to treat cancer, particularly alkylating agents and topoisomerase inhibitors, are known to induce genetic damage in patients.
Christine Roussel, K. Witt, P. B. Shaw, T. Connor   +3 more
semanticscholar   +1 more source