Results 41 to 50 of about 119,383 (327)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B

Brazilian Journal of Medical and Biological Research, 2012
Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can ...
H. Akbaş, K. Yalcin, H. Isi, S. Tekes, A.E. Atay, Z. Akkus, T. Budak   +6 more
doaj   +3 more sources

Monitoring of chromosomal aberrations in natural populations of Pinus pallasiana

Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2012
This paper presents the results of monitoring research of the chromosome aberrations at the stage of anaphase-telophase. The statistical characteristics of dynamics of chromosomal aberrations in populations of Pinus pallasiana D.
V. P. Koba
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Effect of X-Rays on Cytological Traits of Tuta absoluta (Lepidoptera: Gelechiidae) [PDF]

, 2016
The tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is one of the most important pests of tomato. With the purpose of developing environmentally friendly control tactics such as the inherited sterility (IS) technique against this ...
Cagnotti, Cynthia Lorena, Carabajal Paladino, Leonela Zusel, Ferrari, María Edith, Lauría, Juan P., López, Silvia Noelí, Síchová, Jindra   +5 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq

Nature Communications, 2016
Chromosomal aberrations can be detected by global gene expression analysis. Here, the authors report eSNP-Karyotyping, a new method that can detect chromosomal aberrations by measuring the ratio of expression between the two alleles without comparison to
Uri Weissbein, Maya Schachter, Dieter Egli, Nissim Benvenisty   +3 more
doaj   +1 more source

The association between the two more common genetic causes of spermatogenic failure: a 7-year retrospective study

Asian Journal of Andrology, 2020
Chromosomal abnormalities and Y chromosome microdeletions are considered to be the two more common genetic causes of spermatogenic failure. However, the relationship between chromosomal aberrations and Y chromosome microdeletions is still unclear.
Hong-Ge Li, Li-Hong Fan, Bei Liu, Ye-Qing Qian, Min Chen, Yi-Xi Sun, Min-Yue Dong   +6 more
doaj   +1 more source

Chromosomal aberrations and cancer [PDF]

, 2012
Kromosomske aberacije su jedna od glavnih karakteristika stanica raka. U seminaru su prikazane podjelom na balansirane kromosomske aberacije (koje ne gube gene, ali se njihova ekspresija mijenja) i nebalansirane kromosomske aberacije (koje rezultiraju ...
Leko, Petra
core   +2 more sources

Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]

, 2016
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis, Di Giorgio, Marina, Federico, Maria Belén, Gottifredi, Vanesa, Paviolo, Natalia Soledad, Radl, Daniela Betiana, Soria, Gastón, Vallerga, María   +7 more
core   +3 more sources