Results 51 to 60 of about 2,524,105 (337)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Retrospective study revealed integration of CNV-seq and karyotype analysis is an effective strategy for prenatal diagnosis of chromosomal abnormalities

Frontiers in Genetics
Fetal chromosomal abnormalities are the main cause of adverse pregnancy outcomes and are the focus of invasive prenatal diagnosis. Recent studies have demonstrated that various techniques have distinct advantages.
Yunsheng Ge, Jiayan Chen, Yanru Huang, Di Shao, Wenbo Wang, Meijiao Cai, Meihua Tan, Meihua Tan, Jian Zhang   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia [PDF]

, 2008
The intrachromosomal amplification of chromosome 21 (iAMP21) was identifiedas a novel and prognositically important acquired chromosomal abnormality inchildhood acute lymphoblastic leukaemia (ALL).
Robinson, Hazel M., Robinson, Hazel M
core  

Chromosomal abnormalities in primary and secondary amenorrhea [PDF]

Background: Menstruation is an important physiological function of the female reproductive system. The absence of menstruation is called amenorrhea. Many genetic and nongenetic causes are responsible for primary or secondary amenorrhea.
Jasmine Akhter Jahan, Tasnim Binte Ahmed, Bishnu Pada Dey, Saequa Habib   +3 more
core   +1 more source

Nonrandom chromosome abnormalities in cancer An overview [PDF]

, 2015
This chapter discusses neoplastic karyotypes. It emphasizes the difference between primary and secondary changes and address the questions of why, how, when, and where chromosome abnormalities arise; compare numerical and structural aberrations in terms ...
Mitelman, Felix,, Heim, Sverre,, Lund University.   +2 more
core   +1 more source

Chromosomal microarray analysis in 1292 fetuses with ultrasound soft markers during mid-term pregnancy

The Journal of Maternal-Fetal & Neonatal Medicine
Background Soft markers found during mid-term pregnancy ultrasounds can indicate potential chromosomal abnormalities in fetuses. This study evaluates the association between ultrasound soft markers and chromosomal abnormalities, providing insights into ...
Xiaomei Yang, Li Sun, Yasong Xu, Shiyu Sun, Shoulan Zhou, Ping Lv   +5 more
doaj   +1 more source

Clinical Correlates of Autosomal Chromosomal Abnormalities in an Electronic Medical Record–Linked Genome-Wide Association Study

Journal of Investigative Medicine High Impact Case Reports, 2013
Although mosaic autosomal chromosomal abnormalities are being increasingly detected as part of high-density genotyping studies, the clinical correlates are unclear.
Hayan Jouni M.D., Khader Shameer Ph.D., Yan W. Asmann Ph.D., Ribhi Hazin M.D., Mariza de Andrade Ph.D., Iftikhar J. Kullo M.D.   +5 more
doaj   +1 more source

Reproductive outcomes of infertile couples undergoing assisted reproductive technology who are carriers of chromosomal abnormalities: a retrospective cohort study

Annals of Medicine, 2022
Background The aim of this study is to determine whether infertile couples who are carriers of chromosomal abnormalities have distinct cumulative clinical pregnancy and cumulative live birth rates among patients undergoing assisted reproductive ...
Ling Cui, Fang Wang, Yonghong Lin, Min Li   +3 more
doaj   +1 more source

The two sides of chromosomal instability: drivers and brakes in cancer

Signal Transduction and Targeted Therapy
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes ...
R. Hosea, Sharon Hillary, S. Naqvi, Shourong Wu, Vivi Kasim   +4 more
semanticscholar   +1 more source