Results 81 to 90 of about 2,524,105 (337)

Who should be screened for chromosomal abnormalities before ICSI treatment? [PDF]

, 2010
Guidelines on karyotyping infertile men before ICSI treatment are not consistent. Most guidelines recommend chromosomal screening in azoospermic and severe oligozoospermic men, because they are assumed to have the highest risk of abnormalities.
van Ravenswaaij-Arts, C. M. A., Land, J. A., Dul, E. C., J. A. Land, E. C. Dul, J. van Echten-Arends, van Ravenswaaij-Arts, C.M.A., Dul, E.C., Land, J.A., Groen, H., Groen, H.; id_orcid, van Echten-Arends, J., C. M. A. van Ravenswaaij-Arts, H. Groen   +13 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

De novo chromosomal abnormalities and month of conception. [PDF]

, 2006
Objectives We set Out to study the possible relationship between the occurrence of chromosomal abnormalities and the month of conception using data from 7 years of prenatal diagnosis.
DECARLI A, M. Tonelli, A. Decarli, BARLATI, Sergio, S. Barlat, SPECCHIA, Claudia, TONELLI M, C. Specchia   +7 more
core   +1 more source

Population-Based Study of Epilepsy in Infants

Pediatric Neurology Briefs, 2013
Investigators at the Paediatric Neurology Department, Great Ormond Street Hospital for Children, London, and other centers in the UK and USA carried out a population-based study of children, 1-24 months of age, with new-onset epilepsy, ascertained over ...
J Gordon Millichap
doaj   +1 more source

Risk of Chromosomal Abnormalities in Early Spontaneous Abortion after Assisted Reproductive Technology: A Meta-Analysis

PLoS ONE, 2013
Background Studies on the risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology (ART) are relatively controversial and insufficient.
Junzhen Qin, Li-hong Pang, Min-qing Li, Jing Xu, Xing Zhou   +4 more
semanticscholar   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Chromosomal abnormalities associated with mental retardation in female subjects [PDF]

, 2010
Chromosomal abnormalities are thought to be the most common cause of mental retardation (MR). However, apart from a few selected types with typical aneuploidy, like Downs syndrome, Klinefelter syndrome, Turner syndrome, etc., the frequency of detectable ...
Sinha, Swagata, Shaw, Jyoti, Kanchan, Mukhopadhyay, Dutta, Samikshan   +3 more
core   +4 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Genetic Of Mental Retardation [PDF]

, 2005
Mental retardation is a common problem with major implications for a nation’s health, education and community services. The causes of mental retardation have been found to have a definite etiological basis, which may be biochemical, chromosomal ...
Faradz, Sultana M.H.
core