Role of chromosomal instability in cancer progression [PDF]
, 2017 Sarah E. McClelland
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Delayed Cell Death, Giant Cell Formation and Chromosome Instability Induced by X-irradiation in Human Embryo Cells [PDF]
, 1999 Kanaklata Roy +3 more
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DEVELOPMENTAL INSTABILITY IN WILD CHROMOSOMAL HYBRIDS OF THE HOUSE MOUSE [PDF]
, 1999 Noureddine Chatti +4 more
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Mouse Models for Chromosomal Instability
, 2012 Cancer is the result of several genetic alterations that overrule a cell’s protection mechanisms against unscheduled proliferation (Hanahan & Weinberg, 2000). As the vast majority of human tumours show chromosomal instability (CIN), CIN is believed to be an important driver and facilitator of oncogenic transformation.
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Depletion of Securin Increases Arsenite-Induced Chromosome Instability and Apoptosis via a p53-Independent Pathway [PDF]
, 2005 Jui‐I Chao +2 more
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Individual susceptibility to DNA telomerase inhibitors: a study on the chromosome instability induced by 3'-azido-3'-deoxythymidine in lymphocytes of elderly twins [PDF]
, 2004 Daniela Caporossi
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CCRG-02. THE DIFFUSE MIDLINE GLIOMA MUTATIONS, H3.3 K27M AND G34R/V, INHIBIT MITOTIC PHOSPHORYLATION OF SERINE 31, LEADING TO TUMOR FORMATION THROUGH INCREASED CHROMOSOMAL INSTABILITY [PDF]
, 2022 Charles Day +7 more
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Chromosomal instability increases radiation sensitivity
AbstractContinuous chromosome missegregation over successive mitotic divisions, known as chromosomal instability (CIN), is common in cancer. Increasing CIN above a maximally tolerated threshold leads to cell death due to loss of essential chromosomes.
Pippa F. Cosper +15 more
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