Results 241 to 250 of about 54,834 (268)

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

First Report of Genomic Regions Associated With White Leaf Spot Resistance in Brassica napus

Plant Pathology, EarlyView.
The first genomic regions associated with white leaf spot disease resistance (cotyledon and leaf resistance) in Brassica napus have been identified through a genome‐wide association study of 215 genotypes. ABSTRACT White leaf spot, caused by the fungal pathogen Neopseudocercosporella capsellae, is a re‐emerging disease of canola (Brassica napus), as ...
William J. W. Thomas, Ming Pei You, Junrey C. Amas, David Edwards, Surinder S. Banga, Martin J. Barbetti, Jacqueline Batley   +6 more
wiley   +1 more source

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease: or ‘UC or not UC – that is the question’

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Spontaneous canine prostate cancer (PC) is widely considered a pertinent clinical model for the human disease. While over 95% of PC in men are adenocarcinomas, arising from prostatic glandular epithelium, it is increasingly recognised that many canine PC are of urothelial origin, arising within the prostatic urethra or ducts, or through ...
Rachael Thomas, Jennifer A. Luff, Allison N. Dickey, Megan N. Dillon, Isabella G. Livingston, Carter A. Schrag, Steven E. Suter, Matthew Breen   +7 more
wiley   +1 more source

Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics

JOR SPINE, Volume 8, Issue 4, December 2025.
This graphical abstract outlines the workflow to uncovering lactate metabolism‐related mechanisms in intervertebral disc degeneration (IDD). First, three IDD datasets (GSE34095: 3 IDD vs 3 control; GSE147383: 2 IDD vs 2 control; GSE70362: 16 IDD vs 8 control) were sourced from the Gene Expression Omnibus (GEO) database, and 73 lactate metabolism ...
Haiyan Sun, Mingwei He, Jinlei Pang, Xiangfei Guo, Yansong Huo, Jun Ma   +5 more
wiley   +1 more source

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Clinical Utility of Chromosomal Microarray Analysis

Pediatrics, 2012
OBJECTIVE: To test the hypothesis that chromosomal microarray analysis frequently diagnoses conditions that require specific medical follow-up and that referring physicians respond appropriately to abnormal test results.
Berkley R. Powell, Sara L. Minier, Kimberly J. Moles, Jay W. Ellison, S. Annie Morton, Caitlin Valentin, Marc S. Williams, Jill A. Rosenfeld, Timothy Wilks, Jodi Lewis, Nicholas J. Neill, J. Britt Ravnan, Cathryn Walker, Elizabeth Miller, Lisa G. Shaffer, Beth S. Torchia, Kimberly Leiser, Ryan N. Traylor, Jennifer Lantz   +18 more
openaire   +3 more sources

Chromosomal Microarray Analysis and Prenatal Diagnosis

Obstetrical & Gynecological Survey, 2014
Chromosomal microarray analysis (CMA) assesses chromosomal copy number alterations and affords higher resolution when compared with standard karyotype. This review provides the obstetric provider with an update on the technology, use, and controversies concerning CMA utilization in prenatal diagnosis.
Brian L Shaffer, Aaron B. Caughey, Jamie O. Lo, Cori Feist   +3 more
openaire   +3 more sources

Prenatal Diagnosis by Chromosome Microarray Analysis, An Indian Experience

The Journal of Obstetrics and Gynecology of India, 2021
Karyotyping has been the gold standard for prenatal chromosome analysis. The resolution should be higher by chromosome microarray analysis (CMA). The challenge lies in recognizing benign and pathogenic or clinically significant copy number variations (pCNV) and variations of unknown significance (VOUS).
I. C. Verma, Surbhi Mahajan, Pushpa Saviour, Anju Joshi, Sunita Bijarnia-Mahay, Shruti Agarwal, Preeti Paliwal, Arti Joshi, Meena Lall, Ratna Dua Puri   +9 more
openaire   +3 more sources

Chromosomal microarray analysis in ocular developmental anomalies

Expert Review of Molecular Diagnostics, 2012
Ocular developmental anomalies (ODAs) are structural defects of the eye with vari-ous severities, caused by the disruption of the complex process of ocular morpho-genesis. Although the reported prevalence at birth varies greatly, congenital eye mal-formations are rare; they are estimated to occur in four to six per 10,000 neonates in European ...
Brigitte Benzacken, Eva Pipiras, Andrée Delahaye   +2 more
openaire   +2 more sources