Results 241 to 250 of about 109,479 (290)

Understanding the decision of parents to opt‐out of medically actionable secondary findings offered through genome sequencing

Journal of Genetic Counseling, Volume 35, Issue 3, June 2026.
Abstract Genomic sequencing (GS) for patients and families with rare disease creates the opportunity for precise diagnosis as well as the option to learn about medically actionable secondary findings (SF). Debate persists internationally on how to manage the analysis and disclosure of SF, especially in settings where service delivery models for GS are ...
Abigail Hansen, Stephanie Luca, Olivia Moran, Riyana Babul‐Hirji, Teresa B. Coe, Kalin Wilk, Daniel Assamad, Katharine Fooks, Viji Venkataramanan, Salma Shickh, Joyce Yan, Vercancy Wu, Lauren Badalato, Tugce B. Balci, Virginie Beausejour Ladouceur, Lauren Chad, Caitlin Chisholm, Meredith K. Gillespie, Lijia Huang, Olga Jarinova, Lynette Lau, Whiwon Lee, Michael P. Mackley, Christian R. Marshall, Roberto Mendoza‐Londono, Chantal F. Morel, Julie Richer, Sarah Sawyer, Dimitrios James Stavropoulos, Anna Szuto, Mark Tarnopolsky, Anita Villani, Laura Zahavich, Martin J. Somerville, Kym M. Boycott, Wendy J. Ungar, Robin Z. Hayeems   +36 more
wiley   +1 more source

Prenatal diagnosis of 17q12 copy number variants in fetuses via chromosomal microarray analysis - A retrospective cohort study and literature review. [PDF]

Heliyon
Huang R, Ma C, Chen H, Fu F, Han J, Liu L, Li L, Yan S, Lu J, Zhou H, Wang Y, Guo F, Jing X, Li F, Zhen L, Li D, Li R, Liao C.   +17 more
europepmc   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

P772: Optimal amniotic fluid volume required for direct chromosomal microarray analysis

Genetics in Medicine Open
Lina Ibrahim, Elizabeth McCready, Stephanie Winsor   +2 more
doaj   +1 more source

Wheat's war against stripe rust: Integrating host immunity, genomics and breeding for durable resistance

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Wheat (Triticum aestivum L.), a foundation of global food security, faces persistent threats from stripe rust caused by Puccinia striiformis f. sp. tritici (Pst). The pathogen thrives in cool and humid environments and regularly causes epidemics that lead to severe yield losses.
Farkhandah Jan, Mukesh Rathore, Dinesh Kumar Saini, Ayushi Singh, Naeela Qureshi, Nikita Aggarwal, Mahpara Bashir, Mehnaz Shakeel, Vikas Gupta, Sundeep Kumar, Rajeev Kumar Varshney, Reyazul Rouf Mir   +11 more
wiley   +1 more source

Chromosome‐Level Genome and Organ‐Specific Transcriptome of Alnus glutinosa Uncover Lineage‐Specific Innovations in Root Nodule Symbiosis

Plant, Cell &Environment, Volume 49, Issue 6, Page 3003-3021, June 2026.
ABSTRACT Alnus glutinosa is one of only three lineages within the order Fagales capable of establishing root nodule symbiosis (RNS). Although a fragmented genome assembly of A. glutinosa was previously available, its limited quality, combined with the lack of comprehensive transcriptomic resources, has constrained in‐depth comparative and functional ...
Zijian Liu, Xiaoxiao Zhao, Xiuli li, Yong Feng, Linnan Wu, Zhen Wu, Yao Zhong, Qingcheng Qiu, Bo Song, Hang Zhao, Hongbing Liu, Shifeng Cheng   +11 more
wiley   +1 more source

Prenatal diagnosis in fetal right aortic arch using chromosomal microarray analysis and whole exome sequencing: a Chinese single-center retrospective study. [PDF]

Mol Cytogenet
Zhang L, Huang R, Zhou H, Lin X, Guo F, Jing X, Zhang Y, Li F, Li F, Yu Q, Wang D, Chen G, Fu F, Pan M, Han J, Li D, Li R.   +16 more
europepmc   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Reproductive outcomes in couples with recurrent pregnancy loss after embryonic chromosomal microarray analysis. [PDF]

J Assist Reprod Genet
Li Y, Zhou R, Xia Z, Meng L, Huang M, Hu P, Xu Z, Wang Y.   +7 more
europepmc   +1 more source