Results 21 to 30 of about 55,479 (231)

Comparison of Chromosomal Microarray Analysis and Noninvasive Prenatal Testing in Pregnant Women with Fetal Ultrasonic Soft Markers [PDF]

Risk Management and Healthcare Policy
Xianqing Hu,1 Yanjun Hu,1 Hai Wang,2 Caicha Yu,3 Jiayong Zheng,2 Hongping Zhang,1 Jianqiong Zheng1 1Department of Obstetrics and Gynecology, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou ...
Hu X, Hu Y, Wang H, Yu C, Zheng J, Zhang H, Zheng J   +6 more
doaj   +2 more sources

Application of Chromosomal Microarray Analysis in Genetic Reasons of Miscarriage Tissues [PDF]

The Application of Clinical Genetics
Zhen Xu,1– 3 Na Liu,1– 3 Lu Gao,1– 3 Dongyi Yu1– 3 1Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital, Affiliated to Qingdao University, Jinan, Shandong, 250000, People’s Republic of China ...
Xu Z, Liu N, Gao L, Yu D
doaj   +2 more sources

MACAT--microarray chromosome analysis tool [PDF]

Bioinformatics, 2004
By linking differential gene expression to the chromosomal localization of genes, one can investigate microarray data for characteristic patterns of expression phenomena involving sizeable parts of specific chromosomes. We have implemented a statistical approach for identifying significantly differentially expressed chromosome regions.
Toedling, J., Schmeier, S., Heinig, M., Georgi, B., Roepcke, S.   +4 more
openaire   +3 more sources

Application of chromosome microarray analysis in prenatal diagnosis [PDF]

BMC Pregnancy and Childbirth, 2020
Abstract Background To explore the application value of chromosomal microarray analysis (CMA) in prenatal diagnosis. Methods The results of chromosome karyotype analysis and CMA of 477 cases undergoing amniocentesis were analyzed. The results of the no ultrasound abnormality group and the ultrasound abnormality group were compared separately.
Mingjing Xia, Xinhong Yang, Jing Fu, Zhenjuan Teng, Yan Lv, Lixia Yu   +5 more
openaire   +3 more sources

Prenatal diagnosis by chromosomal microarray analysis [PDF]

Fertility and Sterility, 2018
Chromosomal microarray analysis (CMA) is performed either by array comparative genomic hybridization or by using a single nucleotide polymorphism array. In the prenatal setting, CMA is on par with traditional karyotyping for detection of major chromosomal imbalances such as aneuploidy and unbalanced rearrangements.
Brynn, Levy, Ronald, Wapner
openaire   +2 more sources

Optical genome mapping for detection of chromosomal aberrations in prenatal diagnosis

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction Chromosomal aberrations are the most important etiological factors for birth defects. Optical genome mapping is a novel cytogenetic tool for detecting a broad range of chromosomal aberrations in a single assay, but relevant clinical ...
Qinxin Zhang, Yan Wang, Yiyun Xu, Ran Zhou, Mingtao Huang, Fengchang Qiao, Lulu Meng, An Liu, Jing Zhou, Li Li, Xiuqing Ji, Zhengfeng Xu, Ping Hu   +12 more
doaj   +1 more source

A new direction for prenatal chromosome microarray testing: software-targeting for detection of clinically significant chromosome imbalance without equivocal findings [PDF]

PeerJ, 2014
Purpose. To design and validate a prenatal chromosomal microarray testing strategy that moves away from size-based detection thresholds, towards a more clinically relevant analysis, providing higher resolution than G-banded chromosomes but avoiding the ...
Joo Wook Ahn, Susan Bint, Melita D. Irving, Phillipa M. Kyle, Ranjit Akolekar, Shehla N. Mohammed, Caroline Mackie Ogilvie   +6 more
doaj   +2 more sources

Microarray Analysis of Rat Chromosome 2 Congenic Strains [PDF]

Hypertension, 2003
Human essential hypertension is a complex polygenic trait with underlying genetic components that remain unknown. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of human essential hypertension, and a number of reproducible blood pressure regulation quantitative trait loci have been found to map to rat chromosome 2.
Martin W, McBride, Fiona J, Carr, Delyth, Graham, Niall H, Anderson, James S, Clark, Wai K, Lee, Fadi J, Charchar, M Julia, Brosnan, Anna F, Dominiczak   +8 more
openaire   +2 more sources

Chromosomal variants accumulate in genomes of the spontaneous aborted fetuses revealed by chromosomal microarray analysis.

PLoS ONE, 2021
Spontaneous abortion is an impeding factor for the success rates of human assistant reproductive technology (ART). Causes of spontaneous abortion include not only the pregnant mothers' health conditions and lifestyle habits, but also the fetal ...
Sen Li, Lei-Ling Chen, Xing-Hua Wang, Hai-Jing Zhu, Xiao-Long Li, Xie Feng, Lei Guo, Xiang-Hong Ou, Jun-Yu Ma   +8 more
doaj   +2 more sources

Genetic counseling for a prenatal diagnosis of structural chromosomal abnormality with high-resolution analysis using a single nucleotide polymorphism microarray

Clinics and Practice, 2016
A 41-year old pregnant woman underwent amniocentesis to conduct a conventional karyotyping analysis; the analysis reported an abnormal karyotype: 46,XY,add(9)(p24). Chromosomal microarray analysis (CMA) is utilized in prenatal diagnoses.
Akiko Takashima, Naoki Takeshita, Toshihiko Kinoshita   +2 more
doaj   +1 more source