Results 181 to 190 of about 12,009,217 (285)

Therapeutic Vulnerabilities of the Key Genetic Drivers in Leiomyosarcoma. [PDF]

Med Sci (Basel)
Lesovaya EA, Fetisov TI, Bokhyan BY, Maksimova VP, Kulikov EP, Belitsky GA, Kirsanov KI, Yakubovskaya MG.   +7 more
europepmc   +1 more source

Proteolysis Targeting Chimeric-Based Technology in Myeloma and Lymphoma. [PDF]

Mol Cancer Ther
Tigu AB, Ivancuta A, Tomuleasa C, Nistor M, Kegyes D, Cenariu D, Munteanu R, Buzoianu AD, Einsele H, Federico M, Kobold S, Gulei D, Ciechanover A.   +12 more
europepmc   +1 more source

Pancreatic β‐cell mitogenic regeneration in type 1 diabetes: A preclinical review

Diabetic Medicine, EarlyView.
Abstract Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin‐producing pancreatic β‐cells, resulting in hyperglycaemia. The first‐line treatment for symptomatic T1D is exogenous insulin replacement to maintain glycaemic control.
James Cantley, Lisa Logie, Parth Narendran, Colin Dayan   +3 more
wiley   +1 more source

Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures. [PDF]

Mol Genet Genomic Med
Goel H, Goh S, Stuart L.
europepmc   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Metal carcinogens and cancer: integrating genetic and epigenetic perspectives. [PDF]

Front Oncol
Singh S, Phogat P, Saso L, Kukreti S, Bansal A.   +4 more
europepmc   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

Disentangling polymer confinement from specific-folding interactions reveals the drivers of Escherichia coli chromosome organization. [PDF]

Nucleic Acids Res
Delafrouz P, Nesterova T, Harris FE, Farooq H, Du L, Liu J, Ma A, Xiao J, Liang J.   +8 more
europepmc   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy. [PDF]

Cancer Med
Yang Z, Wang J, Wang G, Zhu J, Zhang S, Guo W.   +5 more
europepmc   +1 more source