Results 191 to 200 of about 12,009,217 (285)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex. [PDF]

Nat Commun
Wang Y, Jiang X, Liu X, Jiang X, Wang X, Song X, Chen F, Liu Y, Gou XZ, Tang AH, Sheng S, Yao X, Hou Z, Liu D.   +13 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Current insights into PHF14: molecular features and functional roles. [PDF]

Front Mol Biosci
Gopalakrishnan V, Fahma A, Raju R, Soman S.   +3 more
europepmc   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Epigenetic Alterations in Meningiomas-A Review. [PDF]

Biomedicines
Nafe R, Steidl E, Hattingen E.
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Divergent Healing Trajectories Among Common Mechanical Skin Wound Types in Post‐Smolt Atlantic Salmon (Salmo salar Linnaeus, 1758)

Journal of Fish Diseases, EarlyView.
ABSTRACT Mechanical wounds are a common form of skin damage in Atlantic salmon (Salmo salar Linnaeus, 1758) aquaculture and can predispose fish to secondary infections. Such wounds often arise from routine farming practices, including delousing operations.
Kasidis Chaiyasut, Rose Ruiz Daniels, Christian Karlsen, Barry Bradford, Gunhild Seljehaug Johansson, Miroslava Hansen, Marta Bou, Marianne Vaadal, Lene Rydal Sveen   +8 more
wiley   +1 more source