Results 91 to 100 of about 1,000,004 (376)

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Chromosomal rearrangements in cattle and pigs revealed by chromosome microdissection and chromosome painting

Genetics Selection Evolution, 2003
A pericentric inversion of chromosome 4 in a boar, as well as a case of (2q-;5p+) translocation mosaicism in a bull were analysed by chromosome painting using probes generated by conventional microdissection.
Yerle Martine, Ducos Alain, Pinton Alain
doaj   +1 more source

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1 [PDF]

, 2014
DNA double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombination (HR). The C terminal binding protein–interacting protein (CtIP) is phosphorylated in G2 by cyclin-dependent kinases to initiate resection and ...
Anantha, Anger, Bahassi, Beausoleil, Bernard S. Lopez, Beucher, Boboila, Bunting, Chapman, Chapman, Chen, Darroudi, Davis, de Cárcer, Deckbar, Di Virgilio, Donnianni, Elia, Escribano-Díaz, Feng, Golsteyn, Gotoh, Helmink, Huertas, Huertas, Jackman, Jackson, Jiadong Wang, Julia Künzel, Junjie Chen, Kim, Kühne, Lansing, Lee, Lee-Theilen, Li, Lin Feng, Lukas, Lukas, Löbrich, Mansour, Markus Löbrich, Mladenov, Monika Steinlage, Mosesso, Moynahan, Naim, Nakamura, Nodar Makharashvili, Nussenzweig, Nussenzweig, Olivia Barton, Panier, Pearce, Penny A. Jeggo, Peterson, Polo, Quennet, Rass, Reczek, Reinhardt, Rief, Ronja Diemer-Biehs, Rothkamm, Sandro Conrad, Sartori, Shibata, Steffen C. Naumann, Stephan, Tanya T. Paull, van Gent, van Gent, Wang, Wang, Wang, Weichert, Weichert, Weinstock, Ying, Yu, Yu, Yun, Zhang, Zimmerman, Zimmermann   +84 more
core   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome

Clinical and Experimental Obstetrics & Gynecology, 2020
We report a case of prenatal diagnosis of mosaicism for chromosome t (7; 14) with a favorable fetal outcome. Similar chromosomal abnormalities have been observed in patients with hematologic malignancy.
D. Lu, D. Cao, Q. Zhao, X. Chen
doaj   +1 more source

Wheat-barley hybridization – the last forty years [PDF]

, 2013
Several useful alien gene transfers have been reported from related species into wheat (Triticum aestivum), but very few publications have dealt with the development of wheat/barley (Hordeum vulgare) introgression lines. An overview is given here of
A Blanco, A Cabrera, A Cseh, A Cseh, A Farkas, A Kruse, A Löve, A Löve, A Martín, A Martín, A Martín, A Martín, A Martín, A Mujeeb-Kazi, A Mujeeb-Kazi, A Sepsi, AC Martín, AKMR Islam, AKMR Islam, AKMR Islam, AKMR Islam, AKMR Islam, AKMR Islam, AKMR Islam, AKMR Islam, AKMR Islam, B Wojciechowska, B Wojciechowska, C Doré, C Nakamura, CC Chu, CH Park, D Bai, D Villegas, DA Kerckhoffs, DJ Allendorf, DR Dewey, E Clauss, E Clauss, ED Nagy, ER Sears, ER Sears, ER Sears, G Fedak, G Fedak, G Fedak, G Fedak, G Fedak, G Fedak, G Fedak, G Galiba, G Kimber, Gabriella Linc, GE Hart, GS Sethi, H Bilgic, H Zou, HC Sharma, I Linde-Laursen, I Schubert, IR Barclay, J Fernandez-Escobar, J Jiang, J Lima-Brito, JA Fernandez, JB Thomas, JD Sherman, JI Cubero, JM Surikov, K Kruppa, K Murai, K Sakai, KC Armstrong, KF Mayer, KFX Mayer, L Junming, L Malysheva, LA Pershina, LA Pershina, LA Pershina, LS Dahleen, M Molnár-Láng, M Molnár-Láng, M Molnár-Láng, M Molnár-Láng, M Molnár-Láng, M Molnár-Láng, M Molnár-Láng, MD Gale, Márta Molnár-Láng, N Serizawa, P Barcelo, P Suchánková, PJ Larkin, PK Gupta, PP Jauhar, R Bothmer, R Bothmer, R Riley, R Riley, RA Burton, RA Finch, RJ Henry, S Cho, S Griffiths, S Islam, S Nasuda, S Svitashev, S Taketa, S Taketa, S Taketa, S Taketa, SB Chang, T Ashida, T Koba, T Koba, T Schwarzacher, TR Endo, V Chapman, VK Shumny, VK Shumny, Y Ya-Ping, É Szakács, É Szakács, É Szakács, Éva Szakács   +125 more
core   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages

The Pan African Medical Journal, 2017
Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM.
Wiem Ayed, Islem Messaoudi, Zouhour Belghith, Wajih Hammami, Imen Chemkhi, Nabila Abidli, Helmy Guermani, Rim Obay, Ahlem Amouri   +8 more
doaj   +1 more source

Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study

Hematology Reports, 2012
More than 50% of myeloma cases have normal karyotypes under conventional cytogenetic analysis due to low mitotic activity and content of plasma cells in the bone marrow.
Ivyna Bong Pau Ni, Ng Ching Ching, Chang Kian Meng, Zubaidah Zakaria   +3 more
doaj   +1 more source

Similar Seed Composition Phenotypes Are Observed From CRISPR-Generated In-Frame and Knockout Alleles of a Soybean KASI Ortholog

Frontiers in Plant Science, 2020
The β-ketoacyl-[acyl carrier protein] synthase 1 (KASI) gene has been shown in model plant systems to be critical for the conversion of sucrose to oil.
Kamaldeep S. Virdi, Madison Spencer, Adrian O. Stec, Yer Xiong, Ryan Merry, Gary J. Muehlbauer, Robert M. Stupar   +6 more
doaj   +1 more source