Results 91 to 100 of about 986,967 (334)
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, EarlyView.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans
Eukaryotic Cell, 2005 Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to demonstrate that a chromosomal translocation and segmental
J. A. Fraser +5 more
semanticscholar +1 more source
PARP1 is required for chromosomal translocations
Blood, 2013 Key Points Chromosomal translocations are mediated by PARP1 and can be suppressed by the clinical PARP1 inhibitors.
Christopher R. Cogle +14 more
openaire +4 more sources
Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
Advanced Healthcare Materials, EarlyView.A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li +8 more
wiley +1 more source
Genetics Selection Evolution, 2003 A pericentric inversion of chromosome 4 in a boar, as well as a case of (2q-;5p+) translocation mosaicism in a bull were analysed by chromosome painting using probes generated by conventional microdissection.
Yerle Martine, Ducos Alain, Pinton Alain
doaj +1 more source
Frontiers in Plant Science, 2020 The β-ketoacyl-[acyl carrier protein] synthase 1 (KASI) gene has been shown in model plant systems to be critical for the conversion of sucrose to oil.
Kamaldeep S. Virdi +6 more
doaj +1 more source
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
core +2 more sources
The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing
Advanced Materials, EarlyView.With the growing demand for cell‐based therapies, efficient cellular engineering is crucial. This review calls for greater recognition of mechanobiology principles applied through advanced biomaterial designs, mechanical confinement, and highlights recent advances using micro/nanotechnologies to enhance cell manufacturing.
Huan Ting Ong +8 more
wiley +1 more source
Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages
The Pan African Medical Journal, 2017 Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM.
Wiem Ayed +8 more
doaj +1 more source
Hematology Reports, 2012 More than 50% of myeloma cases have normal karyotypes under conventional cytogenetic analysis due to low mitotic activity and content of plasma cells in the bone marrow.
Ivyna Bong Pau Ni +3 more
doaj +1 more source