Results 121 to 130 of about 982,148 (390)

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Advanced Science, EarlyView.
This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang   +13 more
wiley   +1 more source

Formation of complex and unstable chromosomal translocations in yeast.

PLoS ONE, 2010
Genome instability, associated with chromosome breakage syndromes and most human cancers, is still poorly understood. In the yeast Saccharomyces cerevisiae, numerous genes with roles in the preservation of genome integrity have been identified.
Kristina H Schmidt, Emilie Viebranz, Lillian Doerfler, Christina Lester, Aaron Rubenstein   +4 more
doaj   +1 more source

Clinical findings associated with a de novo partial trisomy 10p11.22p15.3 and monosomy 7p22.3 detected by chromosomal microarray analysis. [PDF]

, 2011
We present the case of an 18-month-old boy with dysmorphic facial features, developmental delay, growth retardation, bilateral clubfeet, thrombocytopenia, and strabismus, whose array CGH analysis revealed concurrent de novo trisomy 10p11.22p15.3 and ...
Dipple, Katrina M, Kohannim, Omid, Peredo, Jane, Quintero-Rivera, Fabiola   +3 more
core   +2 more sources

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene.

Blood, 1997
Chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus at chromosome 14q32 represent a common mechanism of oncogene activation in lymphoid malignancies. In multiple myeloma (MM), the most consistent chromosomal abnormality is the
R. Richelda, D. Ronchetti, L. Baldini, L. Cro, L. Viggiano, R. Marzella, Mariano Rocchi, Takemi Otsuki, L. Lombardi, A. Maiolo, A. Neri   +10 more
semanticscholar   +1 more source

A strategy for the characterization of minute chromosome rearrangements using multiple color fluorescence in situ hybridization with chromosome-specific DNA libraries and YAC clones [PDF]

, 1993
The identification of marker chromosomes in clinical and tumor cytogenetics by chromosome banding analysis can create problems. In this study, we present a strategy to define minute chromosomal rearrangements by multicolor fluorescence in situ ...
A Kallioniemi, Anna Jauch, B Dutrillaux, C Lengauer, C Lengauer, CC Collins, Christoph Lengauer, D Pinkel, Detlev Schindler, DH Ledbetter, DH Ledbetter, GD Johnson, H Telenius, Harold C. Riethman, Helen Donis-Keller, J Grouchy de, J Sambrook, J Wiegant, JG Dauwerse, JS Heslop-Harrison, JW IJdo, Michael R. Speicher, P Lichter, P Lichter, PM Nederlof, PM Nederlof, S Manoir du, Susanne Popp, T Ried, T Ried, T Ried, Thomas Cremer   +31 more
core   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Cytogenetic characterization of the malignant primitive neuroectodermal SK-PN-DW tumor cell line

BMC Cancer, 2019
Background The SK-PN-DW cell line was established in 1979 and is commercially available. Despite the use of this cell line as an in vitro model for functional and therapeutic studies of malignant primitive neuroectodermal tumor (PNET), there is a lack of
Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu, Feng Wang   +7 more
doaj   +1 more source

Chromosomal diversification and karyotype evolution of diploids in the cytologically diverse genus Prospero (Hyacinthaceae) [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Andrew R Leitch, Eva M Temsch, Franz Speta, Hanna Weiss-Schneeweiss, Jang, Tae-Soo, John Parker, Khatere Emadzade, Tae-Soo Jang   +7 more
core   +2 more sources

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source