Results 11 to 20 of about 1,000,004 (376)

Three-dimensional genome architecture influences partner selection for chromosomal translocations in human disease. [PDF]

PLoS ONE, 2012
Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial ...
Jesse M Engreitz, Vineeta Agarwala, Leonid A Mirny   +2 more
doaj   +3 more sources

Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing. [PDF]

Front Endocrinol (Lausanne), 2021
Song H, Shi H, Yang ET, Bu ZQ, Jin ZQ, Huo MZ, Zhang YL.   +6 more
europepmc   +3 more sources

PARP1 is required for chromosomal translocations [PDF]

Blood, 2013
Key Points Chromosomal translocations are mediated by PARP1 and can be suppressed by the clinical PARP1 inhibitors.
Justin, Wray, Elizabeth A, Williamson, Sudha B, Singh, Yuehan, Wu, Christopher R, Cogle, David M, Weinstock, Yu, Zhang, Suk-Hee, Lee, Daohong, Zhou, Lijian, Shao, Martin, Hauer-Jensen, Rupak, Pathak, Virginia, Klimek, Jac A, Nickoloff, Robert, Hromas   +14 more
openaire   +4 more sources

AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones. [PDF]

Mol Cell, 2019
Pannunzio NR, Lieber MR.
europepmc   +3 more sources

Chromosomal Translocation Process

Definitions, 2020
Any type of genetic recombination involving exchange of DNA between nonhomologous chromosomes, which often occurs as the result of non-homologous endjoining of broken DNA strands.

semanticscholar   +1 more source

Identification of complex and cryptic chromosomal rearrangements by optical genome mapping

Molecular Cytogenetics, 2023
Background Optical genome mapping (OGM) has developed into a highly promising method for detecting structural variants (SVs) in human genomes. Complex chromosomal rearrangements (CCRs) and cryptic translocations are rare events that are considered ...
Shanshan Shi, Peizhi Huang, Ruiling Yan, Ruiman Li   +3 more
doaj   +1 more source

Transferring Desirable Genes from Agropyron cristatum 7P Chromosome into Common Wheat. [PDF]

PLoS ONE, 2016
Wheat-Agropyron cristatum 7P disomic addition line Ⅱ-5-1, derived from the distant hybridization between A. cristatum (2n = 4x = 28, PPPP) and the common wheat cv.
Mingjie Lu, Yuqing Lu, Huanhuan Li, Cuili Pan, Yong Guo, Jinpeng Zhang, Xinming Yang, Xiuquan Li, Weihua Liu, Lihui Li   +9 more
doaj   +1 more source

A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Leukemia Research Reports, 2020
Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities.We ...
Alain Chebly, Fady Gh Haddad, Josiane Bassil, Tony Yammine, Rima Korban, Warde Semaan, Fady El Karak, Hampig Raphael Kourie, Chantal Farra   +8 more
doaj   +1 more source

Identification of chromosomal translocation hotspots via scan statistics [PDF]

Bioinform., 2013
MOTIVATION The detection of genomic regions unusually rich in a given pattern is an important undertaking in the analysis of next-generation sequencing data.
I. T. Silva, Rafael A. Rosales, A. J. Holanda, M. Nussenzweig, M. Jankovic   +4 more
semanticscholar   +1 more source

Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21

Molecular Cytogenetics, 2021
Background The translocation t(8;21)(q22;q22) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML) sub type M2.
Shiba Ranjan Mishra, Leena Rawal, Moneeb A. K. Othman, Atul Thatai, Aditi Sarkar, Vandana Lal, Saurabh Kumar Bhattacharya   +6 more
doaj   +1 more source