Results 221 to 230 of about 982,148 (390)

Reciprocal chromosome translocations: analysis of two mutants by interactive computer. [PDF]

, 1972
R W Dickerson, N H Xuong, Oliver W. Jones   +2 more
openalex   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

The Influence of Chromosomal Polymorphism on Embryo Development and Embryonic Molecular Karyotype in Preimplantation Genetic Testing for Chromosomal Translocation. [PDF]

Front Physiol, 2020
Li G, Shi W, Niu W, Xu J, Guo Y, Su Y, Sun Y.   +6 more
europepmc   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Direct ENIT: An easy and reliable tool for gRNA efficacy verification by tracking induced chromosomal translocation. [PDF]

MethodsX, 2020
Lomov NA, Viushkov VS, Zamalutdinov AV, Sboeva MD, Rubtsov MA.   +4 more
europepmc   +1 more source

Duplication 8p syndrome: Studies in a family with a reciprocal translocation between chromosomes 8 and 12 [PDF]

, 1980
Humberto Moreno-Fuenmayor, Karen Meilinger, Donald L. Rucknagel, H. L. Mohrenweiser, E.H.Y. Chu, John M. Optiz   +5 more
openalex   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Maternal translocation (9;18) with two abnormal offspring each with different chromosome derivatives. [PDF]

, 1989
Margaret A. Pearson, Carolyn B. Riske, Judith Allanson   +2 more
openalex   +1 more source

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

Nature Structural &Molecular Biology, 2011
Yu Zhang, M. Jasin
semanticscholar   +1 more source

Chromosome translocations in breast cancer [PDF]

Breast Cancer Research, 2008
Ian O. Ellis, K A Blood, Carlos Caldas, JC Beavis, Jessica C.M. Pole, Susanna L. Cooke, Y Chua, Bee Ling Ng, Nigel P. Carter, Paw Edwards, Koichi Ichimura, Karen Howarth, S-F Chin, Vincent Peter Collins   +13 more
openaire   +2 more sources