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Chromosomal Translocation Process
Definitions, 2020 Any type of genetic recombination involving exchange of DNA between nonhomologous chromosomes, which often occurs as the result of non-homologous endjoining of broken DNA strands.
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Identification of complex and cryptic chromosomal rearrangements by optical genome mapping
Molecular Cytogenetics, 2023 Background Optical genome mapping (OGM) has developed into a highly promising method for detecting structural variants (SVs) in human genomes. Complex chromosomal rearrangements (CCRs) and cryptic translocations are rare events that are considered ...
Shanshan Shi +3 more
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Definitions, 2020 Center for Cancer Research, NCI TEL. 301-496-2202 FAX 301-402-1031 janzs@mail.nih.gov 6809 Airlie Road Warrenton, Virginia 20187 Phone: (540) 347-1300 Fax: (540) 347-5957 Peter Aplan Clara Bloomfield Rafael Casellas Raju Chaganti Riccardo Dalla-Favera ...
S. Janz
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Transferring Desirable Genes from Agropyron cristatum 7P Chromosome into Common Wheat. [PDF]
PLoS ONE, 2016 Wheat-Agropyron cristatum 7P disomic addition line Ⅱ-5-1, derived from the distant hybridization between A. cristatum (2n = 4x = 28, PPPP) and the common wheat cv.
Mingjie Lu +9 more
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Three-dimensional genome architecture influences partner selection for chromosomal translocations in human disease. [PDF]
PLoS ONE, 2012 Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial ...
Jesse M Engreitz +2 more
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A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
Leukemia Research Reports, 2020 Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities.We ...
Alain Chebly +8 more
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Identification of chromosomal translocation hotspots via scan statistics [PDF]
Bioinform., 2013 MOTIVATION The detection of genomic regions unusually rich in a given pattern is an important undertaking in the analysis of next-generation sequencing data.
I. T. Silva +4 more
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Molecular Cytogenetics, 2021 Background The translocation t(8;21)(q22;q22) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML) sub type M2.
Shiba Ranjan Mishra +6 more
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Molecular and classical cytogenetic analyses demonstrate an apomorphic reciprocal chromosomal translocation in Gorilla gorilla [PDF]
, 1992 The existence of an apomorphic reciprocal chromosomal translocation in the gorilla lineage has been asserted or denied by various cytogeneticists. We employed a new molecular cytogenetic strategy (chromosomal in situ suppression hybridization) combined ...
Bigoni, F. +5 more
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RAG-dependent recombination at cryptic RSSs within TEL–AML1 t(12;21)(p13;q22) chromosomal translocation region [PDF]
, 2010 The recombination activating gene (RAG) is a lymphoid-specific endonuclease involved in the V(D)J recombination. It has long been proposed that mis-targeting of RAG proteins is one of the factors contributing to lymphoid chromosomal translocation bearing
Nagata Kyosuke +5 more
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