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Chromosomal translocations in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008Genetic alterations in DNA can lead to cancer when it is present in proto-oncogenes, tumor suppressor genes, DNA repair genes etc. Examples of such alterations include deletions, inversions and chromosomal translocations. Among these rearrangements chromosomal translocations are considered as the primary cause for many cancers including lymphoma ...
Nambiar, Mridula +2 more
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Reciprocal translocation and the Philadelphia chromosome
Human Genetics, 1978We examined metaphases from three patients with chronic myeloid leukaemia and a typical Philadelphia chromosome with one chromosome 9 as the recipient to determine whether the 9q+22q- translocation is reciprocal. Good quality G-banded photographs of the chromosomes concerned were subjected to light absorption density analysis.
Brenda M. Page, Jessie L. Watt
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Mechanisms of oncogenic chromosomal translocations
Annals of the New York Academy of Sciences, 2014Chromosome translocations are caused by inappropriate religation of two DNA double‐strand breaks (DSBs) in heterologous chromosomes. These DSBs can be generated by endogenous or exogenous sources. Endogenous sources of DSBs leading to translocations include inappropriate recombination activating gene (RAG) or activation‐induced deaminase (AID) activity
Jac A. Nickoloff +7 more
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2018
The sex chromosomes (gonosomes) are different, and sex chromosome translocations need to be considered separately from translocations between autosomes. A sex chromosome can engage in translocation with an autosome, with the other sex chromosome, or even with its homolog.
R. J McKinlay Gardner, David J. Amor
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The sex chromosomes (gonosomes) are different, and sex chromosome translocations need to be considered separately from translocations between autosomes. A sex chromosome can engage in translocation with an autosome, with the other sex chromosome, or even with its homolog.
R. J McKinlay Gardner, David J. Amor
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Chromosome Translocation in Peripheral Neuroepithelioma
New England Journal of Medicine, 1984PERIPHERAL neuroepithelioma (peripheral neuroblastoma) is an uncommon malignant tumor of the peripheral nervous system with a histologic appearance similar to that of classical childhood neuroblast...
Mark A. Israel +5 more
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Nondisjunction of a translocation-chromosome t(4;13)
Human Genetics, 1981We have studied a male infant with multiple congenital anomalies due to a double derivative chromosome 13 resulting from an inherited balanced reciprocal translocation t(4;13)(q23;q12).
M. Westmeier +5 more
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Histone influences on chromosomal translocations [PDF]
Nature Reviews Genetics, 2015 A new report shows that histone modification patterns influence the occurrence of chromosomal translocations.
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DNA Repair and Chromosomal Translocations
2015The balance between DNA damage, especially double strand breaks, and DNA damage repair is a critical determinant of chromosomal translocation frequency. The non-homologous end-joining repair (NHEJ) pathways seem to play the major role in the generation of chromosomal translocations.
Purvi M. Kakadia, Stefan K. Bohlander
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Complex chromosomal translocations in the Philadelphia chromosome leukemias
Cancer Genetics and Cytogenetics, 1991Joining of the BCR and ABL genes is an essential feature of the group of human leukemias characterized by the Philadelphia chromosome and there is recent evidence that the human BCR-ABL fusion gene induces leukemia in experimental animals. Joining of these two genes is the result of cytogenetic translocation, usually the t(9;22)(q34;q11), but sometimes
Christine M. Morris, Peter H. Fitzgerald
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The mystery of chromosomal translocations in cancer
Cytogenetic and Genome Research, 2007Chromosomal translocations in human cancer may result in products that can be suppressed by targeting drugs. An example is bcr-abl tyrosine kinase in chronic myelogenous leukemia that can be treated with imatinib mesylate. However, the mechanisms of translocations or exchanges of chromosomal segments are virtually unknown.
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