Mitochondrial dynamics in autoimmune diseases
Rheumatology &Autoimmunity, EarlyView.Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma +5 more
wiley +1 more source
A novel association of campomelic dysplasia and hydrocephalus with an unbalanced chromosomal translocation upstream of SOX9. [PDF]
Cold Spring Harb Mol Case Stud, 2018 Antwi P +6 more
europepmc +1 more source
Novel LPIN2 mutations in Majeed syndrome induce NF‐κB pathway activation
Rheumatology &Autoimmunity, EarlyView.This study identifies novel LPIN2 mutations in Majeed syndrome that induce NF‐κB pathway activation, linking defective LPIN2 function to aberrant inflammation in this rare autoinflammatory disorder.
Yibing Han +4 more
wiley +1 more source
Double chromosomal translocation in an infertile man: one-step FISH meiotic segregation analysis and reproductive prognosis. [PDF]
J Assist Reprod Genet, 2019 Pierron L +12 more
europepmc +1 more source
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Small, EarlyView.This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai +5 more
wiley +1 more source
AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones. [PDF]
Mol Cell, 2019 Pannunzio NR, Lieber MR.
europepmc +1 more source
CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy
VIEW, EarlyView.Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma +6 more
wiley +1 more source
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias [PDF]
, 2005 Benoit, Yves +20 more
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