Results 291 to 300 of about 1,000,004 (376)

Double chromosomal translocation in an infertile man: one-step FISH meiotic segregation analysis and reproductive prognosis. [PDF]

J Assist Reprod Genet, 2019
Pierron L, Irrmann A, de Chalus A, Bloch A, Heide S, Rogers E, Lédée N, Prat-Ellenberg L, Coussement A, Dupont JM, Cassuto NG, Siffroi JP, Rouen A.   +12 more
europepmc   +1 more source

Analysis of chromosomes in molecular tumor and radiation cytogenetics: Approaches, apllications, perspectives [PDF]

, 1992
Cremer, Christoph, Cremer, Thomas
core  

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Novel LPIN2 mutations in Majeed syndrome induce NF‐κB pathway activation

Rheumatology &Autoimmunity, EarlyView.
This study identifies novel LPIN2 mutations in Majeed syndrome that induce NF‐κB pathway activation, linking defective LPIN2 function to aberrant inflammation in this rare autoinflammatory disorder.
Yibing Han, Renmei Cai, Yuanxuan Ma, Shiguo Liu, Bin Liu   +4 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple Myeloma [PDF]

Ze Wang, Mengjie Guo, Xichao Yu, Yi Sun, Haowen Bai, Lianxin Zhou, Zihao Liu, Hongming Huang, Chong Wang, Hong Liu, Chunyan Gu, Ye Yang   +11 more
openalex   +1 more source

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, EarlyView.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source

A novel male 2;4;14 complex chromosomal translocation with normal semen parameters but 100% embryonic aneuploidy. [PDF]

J Assist Reprod Genet, 2018
Mas J, Sabouni R, Bocca S.
europepmc   +1 more source

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, EarlyView.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing. [PDF]

Blood Adv, 2018
Schneidawind C, Jeong J, Schneidawind D, Kim IS, Duque-Afonso J, Wong SHK, Iwasaki M, Breese EH, Zehnder JL, Porteus M, Cleary ML.   +10 more
europepmc   +1 more source