Results 331 to 340 of about 1,000,004 (376)

Reciprocal translocation and the Philadelphia chromosome

Human Genetics, 1978
We examined metaphases from three patients with chronic myeloid leukaemia and a typical Philadelphia chromosome with one chromosome 9 as the recipient to determine whether the 9q+22q- translocation is reciprocal. Good quality G-banded photographs of the chromosomes concerned were subjected to light absorption density analysis.
J L, Watt, B M, Page
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Mechanisms of oncogenic chromosomal translocations

Annals of the New York Academy of Sciences, 2014
Chromosome translocations are caused by inappropriate religation of two DNA double‐strand breaks (DSBs) in heterologous chromosomes. These DSBs can be generated by endogenous or exogenous sources. Endogenous sources of DSBs leading to translocations include inappropriate recombination activating gene (RAG) or activation‐induced deaminase (AID) activity
Michael, Byrne, Justin, Wray, Brian, Reinert, Yuehan, Wu, Jac, Nickoloff, Suk-Hee, Lee, Robert, Hromas, Elizabeth, Williamson   +7 more
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Nondisjunction of a translocation-chromosome t(4;13)

Human Genetics, 1981
We have studied a male infant with multiple congenital anomalies due to a double derivative chromosome 13 resulting from an inherited balanced reciprocal translocation t(4;13)(q23;q12).
M, Westmeier, P, Kaiser, W, Hellwig-Beato, E D, Steuber, G, Körver, I, Ribhegge   +5 more
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Chromosome Translocation in Peripheral Neuroepithelioma

New England Journal of Medicine, 1984
PERIPHERAL neuroepithelioma (peripheral neuroblastoma) is an uncommon malignant tumor of the peripheral nervous system with a histologic appearance similar to that of classical childhood neuroblast...
J, Whang-Peng, T J, Triche, T, Knutsen, J, Miser, E C, Douglass, M A, Israel   +5 more
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Sex chromosome translocations and speciation

Nature, 1976
SPECIATION is the primary process of cladogenetic evolution. It is generally agreed that genetic divergence sufficient to produce reproductive isolation among populations is acquired in the allopatric state1–4. One of the major problems of evolutionary genetics is, then, characterisation of the genetic differences which actually produce the ...
M L, Tracey, S A, Espinet
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DNA Repair and Chromosomal Translocations

2015
The balance between DNA damage, especially double strand breaks, and DNA damage repair is a critical determinant of chromosomal translocation frequency. The non-homologous end-joining repair (NHEJ) pathways seem to play the major role in the generation of chromosomal translocations.
Stefan K, Bohlander, Purvi M, Kakadia
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Translocation chromosome karyotypes of the Robertsonian translocation carriers' embryos

Fertility and Sterility, 2010
To explore the translocation karyotypes of the Robertsonian translocation (RT) carriers' embryos in their preimplantation genetic diagnosis (PGD) cycles.Retrospective.University-affiliated IVF center.A total of 35 RT carrier couples underwent 39 blastomere PGD cycles from August 2005 to June 2008.The PGD analysis of embryos.Meiotic segregation patterns
Huang, Jin, Liu, Ping, Qiao, Jie, Lian, Ying, Chen, Yongjian   +4 more
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Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma

Nature Cell Biology, 2020
D. Liao, L. Zhong, Junqiang Yin, Cuiling Zeng, Xin Wang, Xingchuan Huang, Jinna Chen, Hong Zhang, Ruhua Zhang, X. Guan, X. Shuai, J. Sui, Song Gao, Wuguo Deng, Y. Zeng, Jingnian Shen, Jian Chen, Tiebang Kang   +17 more
semanticscholar   +1 more source

The mystery of chromosomal translocations in cancer

Cytogenetic and Genome Research, 2007
Chromosomal translocations in human cancer may result in products that can be suppressed by targeting drugs. An example is bcr-abl tyrosine kinase in chronic myelogenous leukemia that can be treated with imatinib mesylate. However, the mechanisms of translocations or exchanges of chromosomal segments are virtually unknown.
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Chromosomal translocations in human cancer

Nature, 1994
Chromosomal abnormalities in tumours were recognized at the end of the last century but their significance has only recently become clear. Distinct translocations in leukaemias and in solid tumours lead to the activation of proto-oncogene products or, more commonly, creation of tumour-specific fusion proteins.
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