Results 41 to 50 of about 982,148 (390)

Detection of t(7;12)(q36;p13) in paediatric leukaemia using dual colour fluorescence in situ hybridisation [PDF]

, 2015
The identification of chromosomal rearrangements is of utmost importance for the diagnosis and classification of specific leukaemia subtypes and therefore has an impact on therapy choices in individual cases.
Federico, C, Owoka, T, Saccone, S, Tosi, S, Vetter, M   +4 more
core   +2 more sources

Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM.

Blood, 2012
Immune defect in ataxia telangiectasia patients has been attributed to either the failure of V(D)J recombination or class-switch recombination, and the chromosomal translocation in their lymphoma often involves the TCR gene.
T. Isoda, M. Takagi, J. Piao, Shun Nakagama, Masaki Sato, K. Masuda, T. Ikawa, M. Azuma, T. Morio, H. Kawamoto, S. Mizutani   +10 more
semanticscholar   +1 more source

Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization [PDF]

, 1993
A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p−, and a 21q+. These derivative chromosomes could not be defined by GTG-banding.
Anna Jauch, Brothman, Burke, Christoph Lengauer, Collins, Cooke, Cremer, Cremer, Jauch, Klever, Lengauer, Lengauer, Lengauer, Lichter, Lichter, Marosi, Masafumi Taniwaki, Michael R. Speicher, Moyzis, Pinkel, Pinkel, Rowley, Selleri, Smit, Speleman, Susanne Popp, Thomas Cremer   +26 more
core   +1 more source

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

Cell Reports, 2015
Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to experimental limitations, fundamental characteristics of karyotypic changes in cancer are poorly understood.
Ashley M. Laughney, Sergi Elizalde, Giulio Genovese, Samuel F. Bakhoum   +3 more
doaj   +1 more source

Mechanism of Fragility at BCL2 Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation*

Journal of Biological Chemistry, 2012
Background: The mechanism of fragility at mcr during t(14;18) translocation is not known. Results: RAGs nick mcr using a unique mechanism involving the CCACCTCT motif, which is critical for its fragility.
Mridula Nambiar, S. Raghavan
semanticscholar   +1 more source

Novel t(7;10)(p22;p24) along with NPM1 mutation in patient with relapsed acute myeloid leukemia

Annals of Saudi Medicine, 2013
Chromosomal abnormalities/genetic mutations associated with hematological malignancies alter the structure and function of genes controlling cell proliferation and differentiation through multiple and complex pathways, resulting different clinical ...
Santhi Sarojam, Sureshkumar Raveendran, Geetha Narayanan, Hariharan Sreedharan   +3 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

PLoS Genetics, 2011
Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells.
Deni̇z Şi̇mşek, E. Brunet, Sunnie Y. Wong, S. Katyal, Yankun Gao, P. Mckinnon, J. Lou, Lei Zhang, James Li, E. Rebar, P. Gregory, M. Holmes, M. Jasin   +12 more
semanticscholar   +1 more source

Pericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes [PDF]

, 2001
In mammals, Robertsonian (Rb) translocation (the joining of two telo/acrocentric chromosomes at their centromere to form a metacentric) is the most effective process in chromosomal evolution leading to speciation; its occurrence also affects human health
Capanna, E., Garagna, S., Marziliano, N., Redi, C.A., Searle, J.B., Zuccotti, M.   +5 more
core   +3 more sources

The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases

Chromosoma, 2022
Abstract Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several studies in the Arab world, but the frequency and spectrum of these translocations are not well characterized.
Hadeel T. Zedan, Fatma H. Ali, Hatem Zayed   +2 more
openaire   +3 more sources