Results 41 to 50 of about 986,967 (334)

LMO2 at 25 years: a paradigm of chromosomal translocation proteins

Open Biology, 2015
LMO2 was first discovered through proximity to frequently occurring chromosomal translocations in T cell acute lymphoblastic leukaemia (T-ALL). Subsequent studies on its role in tumours and in normal settings have highlighted LMO2 as an archetypical ...
J. Chambers, T. Rabbitts
semanticscholar   +1 more source

Detection of t(7;12)(q36;p13) in paediatric leukaemia using dual colour fluorescence in situ hybridisation [PDF]

, 2015
The identification of chromosomal rearrangements is of utmost importance for the diagnosis and classification of specific leukaemia subtypes and therefore has an impact on therapy choices in individual cases.
Federico, C, Owoka, T, Saccone, S, Tosi, S, Vetter, M   +4 more
core   +2 more sources

Occupational exposure to pesticides and occurrence of the chromosomal translocation t(14;18) among farmers in Jordan

Toxicology Reports, 2016
Background: An increased incidence of non-Hodgkin’s lymphoma (NHL) has been reported in farmers and other occupational groups working with pesticides. In these individuals, an increased prevalence of the chromosomal translocation t(14;18)(q32;q21), one ...
Bara’a M. Qaqish, Osama Al-Dalahmah, Yousef Al-Motassem, Abdelkader Battah, Said S. Ismail   +4 more
doaj   +1 more source

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

Nucleic Acids Research, 2014
In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ).
A. Soni, M. Siemann, Martha Grabos, T. Murmann, G. Pantelias, G. Iliakis   +5 more
semanticscholar   +1 more source

Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization [PDF]

, 1990
A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of ...
Anna Jauch, Bickmore, Cremer, Cremer, de Grouchy, Dutrillaux, Holmquist, Johannes Wienberg, Lalley, Lichter, Lichter, Lichter, O'Brien, Ohno, Pinkel, Roscoe Stanyon, Seuánez, Stanyon, Thomas Cremer, Van Dilla, Weber, Wienberg, Yunis   +22 more
core   +1 more source

The cellular etiology of chromosome translocations [PDF]

Current Opinion in Cell Biology, 2013
Chromosome translocations are the most severe form of genome defect. Translocations represent the end product of a series of cellular mistakes and they form after cells suffer multiple DNA double strand breaks (DSBs), which evade the surveillance mechanisms that usually eliminate them.
Vassilis Roukos, Tom Misteli, Bharat Burman   +2 more
openaire   +3 more sources

Novel t(7;10)(p22;p24) along with NPM1 mutation in patient with relapsed acute myeloid leukemia

Annals of Saudi Medicine, 2013
Chromosomal abnormalities/genetic mutations associated with hematological malignancies alter the structure and function of genes controlling cell proliferation and differentiation through multiple and complex pathways, resulting different clinical ...
Santhi Sarojam, Sureshkumar Raveendran, Geetha Narayanan, Hariharan Sreedharan   +3 more
doaj   +1 more source

A strategy for the characterization of minute chromosome rearrangements using multiple color fluorescence in situ hybridization with chromosome-specific DNA libraries and YAC clones [PDF]

, 1993
The identification of marker chromosomes in clinical and tumor cytogenetics by chromosome banding analysis can create problems. In this study, we present a strategy to define minute chromosomal rearrangements by multicolor fluorescence in situ ...
A Kallioniemi, Anna Jauch, B Dutrillaux, C Lengauer, C Lengauer, CC Collins, Christoph Lengauer, D Pinkel, Detlev Schindler, DH Ledbetter, DH Ledbetter, GD Johnson, H Telenius, Harold C. Riethman, Helen Donis-Keller, J Grouchy de, J Sambrook, J Wiegant, JG Dauwerse, JS Heslop-Harrison, JW IJdo, Michael R. Speicher, P Lichter, P Lichter, PM Nederlof, PM Nederlof, S Manoir du, Susanne Popp, T Ried, T Ried, T Ried, Thomas Cremer   +31 more
core   +1 more source

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

PLoS Genetics, 2011
Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells.
Deni̇z Şi̇mşek, E. Brunet, Sunnie Y. Wong, S. Katyal, Yankun Gao, P. Mckinnon, J. Lou, Lei Zhang, James Li, E. Rebar, P. Gregory, M. Holmes, M. Jasin   +12 more
semanticscholar   +1 more source

A family case of fertile human 45,X,psu dic(15;Y) males [PDF]

, 2006
We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal
Andersson M, Baumstark A, Buonadonna AL, C.S. Nagarajappa, Callen DF, Charchar FJ, Fracarro M, Freije D, Gal A, Haaf T, Hsu TC, I. Hansmann, I. Palaniappan, Koiffmann CP, Ma NS, Maserati E, Matthey R, N. Chandra, P.M. Gopinath, R. Wimmer, Ried T, Schempp W, Schiebel K, Schmid M, Siffroi JP, Subrt I, Tiemeier DC, W. Schempp, Weber B, White LM   +29 more
core   +1 more source