Results 81 to 90 of about 982,148 (390)

Origin of Chromosomal Translocations in Lymphoid Cancer [PDF]

Cell, 2010
Aberrant fusions between heterologous chromosomes are among the most prevalent cytogenetic abnormalities found in cancer cells. Oncogenic chromosomal translocations provide cells with a proliferative or survival advantage. They may either initiate transformation or be acquired secondarily as a result of genomic instability.
Michel C. Nussenzweig, Michel C. Nussenzweig, André Nussenzweig   +2 more
openaire   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation

Human Mutation, 2009
Clustering of inhibitory γ‐aminobutyric acidA (GABAA) and glycine receptors at synapses is thought to involve key interactions between the receptors, a “scaffolding” protein known as gephyrin and the RhoGEF collybistin.
V. Kalscheuer, L. Musante, Cheng Fang, K. Hoffmann, C. Fuchs, E. Carta, E. Deas, K. Venkateswarlu, C. Menzel, R. Ullmann, N. Tommerup, L. Dalprà, A. Tzschach, A. Selicorni, B. Lüscher, H. Ropers, K. Harvey, R. Harvey   +17 more
semanticscholar   +1 more source

Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]

, 2006
Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko, Morishima, Tsuneo, Ninomiya, Shinsuke, Shinozuka, Masako, Une, Tomoka, Yokoyama, Yuji   +5 more
core   +1 more source

Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli

FEBS Open Bio, EarlyView.
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa, Yasushi Shigeri, Shingo Fujisaki   +2 more
wiley   +1 more source

Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics

Haematologica, 2008
Primary extramedullary plasmacytoma is an indolent neoplasm that infrequently converts to multiple myeloma. Since cytogenetic data on extramedullary plasmacytoma are lacking, we studied 38 cases of this type of neoplasm by fluorescence in situ ...
Karin Bink, Eugenia Haralambieva, Marcus Kremer, German Ott, Christine Beham-Schmid, Laurence de Leval, Suat Cheng Peh, Hubert R. Laeng, Uta Jütting, Peter Hutzler, Leticia Quintanilla-Martinez, Falko Fend   +11 more
doaj   +1 more source

Primary tracheal synovial sarcoma: a rare clinical entity with diagnostic challenges

Journal of the Egyptian National Cancer Institute, 2020
Background The incidence of primary tracheal tumors is very low. Tracheal synovial sarcoma (SS) is even an extremely rare entity. Diagnosis of tracheal SS can be achieved with chromosomal translocation studies along with immunohistochemistry. Margin-free
Navin Kumar, Seema Kaushal, Kanaklata Kanaklata, Manoj Gowda, Sunil Kumar   +4 more
doaj   +1 more source

Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization [PDF]

, 1991
In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2.
Anna Jauch, Barbara Smialek, Cremer, Cremer, Dauwerse, Fuscoe, ISCN, ISCN, Jauch, Jing Ying Qiu, Kievits, Landegent, Lichter, Lichter, Lichter, Lichter, Lux, Pinkel, Pinkel, Reinhard Becher, Ried, Susanne Popp, Thomas Cremer, Wada   +23 more
core   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Criteria to evaluate patterns of segmental and complete aneuploidies in preimplantation genetic testing for aneuploidy results suggestive of an inherited balanced translocation or inversion

F&S Reports, 2021
Objective: To define criteria for determining when preimplantation genetic testing for aneuploidy (PGT-A) results are suggestive of a potential balanced chromosomal rearrangement in the egg or sperm source and warrant karyotyping.
Alyssa C. Snider, Ph.D., C.G.C., Tristan Darvin, M.S., Lauren Spor, B.S., Adedoyin Akinwole, M.P.H., Cengiz Cinnioglu, Ph.D., Refik Kayali, Ph.D.   +5 more
doaj