Results 11 to 20 of about 69,824 (308)

In Silico Methods for Chromosome Damage [PDF]

, 2022
Due to the link with serious adverse health effects, genotoxicity is an important toxicological endpoint in each regulatory setting with respect to human health, including for pharmaceuticals.
I. Van Overmeire, G.J. Lavado, Diego Baderna, Giovanna J. Lavado, Ilse Van Overmeire, Domenico Gadaleta, D. Baderna, B. Mertens, D. Gadaleta, Birgit Mertens   +9 more
core   +1 more source

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes [PDF]

, 1988
Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter.
Cremer, Thomas, Manuelidis, L., Lichter, Peter, Borden, J., Ward, D. C.   +4 more
core   +1 more source

Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization [PDF]

, 1990
Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes
Cremer, Thomas, Emmerich, Patricia, Cremer, Christoph, Lichter, Peter, Popp, Susanne   +4 more
core   +1 more source

Chromosome aberrations frequency in peripheral blood lymphocytes in young tobacco smoking and non-smoking people

Journal of Health Sciences, 2016
Introduction: Cigarette smoking is associated with severe health problems, especially cancers. In addition, cigarette smoking causes different genotoxic effects. Chromosome aberrations are one of well-known intermediate end points in carcinogenesis.
Anja Haverić, Sanin Haverić, Slavka Ibrulj   +2 more
doaj   +1 more source

Aberrations of chromosome 8 in myelodysplastic syndromes: Clinical and biological significance [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2006
Introduction: Rearrangements of any single chromosome in human karyotype have been reported in patients with pMDS. Objective: To examine the role of aberrations of chromosome 8 in pathogenesis, clinical presentation and progression of myelodysplastic ...
Marisavljević Dragomir, Pantić-Ludoški Milena, Novak Angelina, Đorđević Vesna   +3 more
doaj   +1 more source

Chromosome breakpoint distribution of damage induced in peripheral blood lymphocytes by densely ionising radiation [PDF]

, 2006
Purpose: To assess the chromosomal breakpoint distribution in human peripheral blood lymphocytes (PBL) after exposure to a low dose of high linear energy transfer (LET) α-particles using the technique of multiplex fluorescence in situ hybridisation (m ...
Anderson, RM, Papworth, DG, Sumption, ND, Goodhead, DT   +3 more
core   +1 more source

Effect of met-enkephalin on chromosomal aberrations in the lymphocytes of the peripheral blood of patients with multiple sclerosis

Biomolecules & Biomedicine, 2014
Endogenious opiod met-enkephalin throughout previous research manifested cytoprotective and anti-inflammatory effects. Previous research suggests that met-enkephalin has cytogenetic effects.
Maida Rakanović-Todić, Lejla Burnazović-Ristić, Slavka Ibrulj, Nedžad Mulabegović   +3 more
doaj   +1 more source

Induction of chromosome shattering by ultraviolet light and caffeine [PDF]

, 1981
Synchronized and asynchronously growing cells of a V79 sub-line of the Chinese hamster were either partial-cell irradiation (λ, 254 nm) or laser-UV-microirradiated (λ, 257 nm).
Cremer, Thomas, Cremer, Christoph, Zimmer, J., Zorn, Christian   +3 more
core   +1 more source

Ability of Fourteen Chemical Agents Used in Dental Practice to Induce Chromosome Aberrations in Syrian Hamster Embryo Cells

Journal of Pharmacological Sciences, 2005
To assess the genotoxicity of 14 chemical agents used in dental practice, the ability of these agents to induce chromosome aberrations was examined using Syrian hamster embryo (SHE) cells.
Hirohito Hikiba, Eiko Watanabe, J. Carl Barrett, Takeki Tsutsui   +3 more
doaj   +1 more source

Chromosome 7 aneuploidy in clear cell and papillary renal cell carcinoma: Detection using silver in situ hybridization technique

Indian Journal of Pathology and Microbiology, 2013
Background: Chromosome 7 aberrations in renal cell carcinoma (RCC) have been reported in papillary renal cell carcinoma (pRCC) and clear cell renal cell carcinoma (ccRCC).
Jayalakshmi Pailoor, Retnagowri Rajandram, Ning Yi Yap, Keng Lim Ng, Zhiqiang Wang, Krishnan R Iyengar   +5 more
doaj   +1 more source