Results 31 to 40 of about 812,203 (315)

Comparative analysis of the yields of dicentrics and chromosomal translocations [PDF]

arXiv, 2023
Purpose: Chromosomal dicentrics and translocations are commonly employed as biomarkers to estimate radiation doses. The main goal of this article is to perform a comparative analysis of yields of both types of aberrations. The objective is to determine if there are relevant distinctions between both yields, allowing for a comprehensive assessment of ...
arxiv  

Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control [PDF]

Eur. Phys. J. D 73, 64 (2019), 2019
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy. Our theoretical model consists of a system of Markov chains in microscopic and macroscopic spatio-temporal landscapes, i.e., stochastic birth-death processes of cells in ...
arxiv   +1 more source

Dose assessment by quantification of chromosome aberrations and micronuclei in peripheral blood lymphocytes from patients exposed to gamma radiation [PDF]

Genetics and Molecular Biology, 2005
Scoring of unstable chromosome aberrations (dicentrics, rings and fragments) and micronuclei in circulating lymphocytes are the most extensively studied biological means for estimating individual exposure to ionizing radiation (IR), which can be used as ...
Isvânia Silva-Barbosa, Símey Pereira-Magnata, Ademir Amaral, Graça Sotero, Homero Cavalcanti Melo   +4 more
doaj   +1 more source

Chromosome Segregation Errors Generate a Diverse Spectrum of Simple and Complex Genomic Rearrangements

Nature Genetics, 2019
Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELECT, to ...
P. Ly, Simon F. Brunner, Ofer Shoshani, D. H. Kim, Weijie Lan, Tatyana Pyntikova, A. Flanagan, S. Behjati, D. Page, P. Campbell, D. Cleveland   +10 more
semanticscholar   +1 more source

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: Structural chromosomal aberrations in blood lymphocytes represent a biomarker for cellular damage caused by genotoxic carcinogens and are an indicator of increased cancer risk.
Ludovit Musak, Zdenek Smerhovsky, Erika Halasova, Oto Osina, Lucia Letkova, Ludmila Vodickova, Veronika Polakova, Janka Buchancova, Kari Hemminki, Pavel Vodicka   +9 more
doaj   +1 more source

Modelling radiation-induced cell cycle delays [PDF]

Published online: Radiation and Environmental Biophysics, 2009. The original publication is available at http://www.springerlink.com/content/l33041651m10815w/, 2009
Ionizing radiation is known to delay the cell cycle progression. In particular after particle exposure significant delays have been observed and it has been shown that the extent of delay affects the expression of damage such as chromosome aberrations.
arxiv   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Chromosome Aberrations of East Asian Bullfrog (Hoplobatrachus rugulosus) around a Gold Mine Area with Arsenic Contamination [PDF]

EnvironmentAsia, 2016
The objectives of this study are to investigate the chromosome aberrations of the East Asian Bullfrog (Hoplobatrachus rugulosus) in the gold mine area compared to an unaffected area. Three H.
Atidtaya Suttichaiya , Arthone Khammanichanh , Isara Patawang , Manop Sriuttha , Alongklod Tanamtong , Lamyai Neeratanaphan   +5 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Computer aided analysis of additional chromosome aberrations in Philadelphia chromosome positive acute lymphoblastic leukaemia using a simplified computer readable cytogenetic notation

BMC Bioinformatics, 2003
Background The analysis of complex cytogenetic databases of distinct leukaemia entities may help to detect rare recurring chromosome aberrations, minimal common regions of gains and losses, and also hot spots of genomic rearrangements.
Mohr Brigitte, Jauch Anna, Heinze Barbara, Fonatsch Christa, Balz Harald, Bradtke Jutta, Schoch Claudia, Rieder Harald   +7 more
doaj   +1 more source