Results 51 to 60 of about 409,247 (302)

Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes [PDF]

, 1984
In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome.
Back, W., Cremer, Thomas, Rappold, Gudrun A., Cremer, Christoph, Bogenberger, J., Cooke, H. J.   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes [PDF]

, 1988
Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter.
Cremer, Thomas, Manuelidis, L., Lichter, Peter, Borden, J., Ward, D. C.   +4 more
core   +1 more source

Simultaneous detection of genomic imbalance in patients receiving preimplantation genetic testing for monogenic diseases (PGT-M)

Frontiers in Genetics, 2022
Background: Preimplantation genetic test for monogenic disorders (PGT-M) has been used to select genetic disease-free embryos for implantation during in vitro fertilization (IVF) treatment.
Lin Yang, Lin Yang, Yan Xu, Yan Xu, Jun Xia, Jun Xia, Huijuan Yan, Chenhui Ding, Chenhui Ding, Qianyu Shi, Yujing Wu, Ping Liu, Jiafu Pan, Jiafu Pan, Yanhong Zeng, Yanhong Zeng, Yanyan Zhang, Fang Chen, Hui Jiang, Yanwen Xu, Yanwen Xu, Wei Li, Wei Li, Canquan Zhou, Canquan Zhou, Ya Gao, Ya Gao   +26 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mathematical modelling of whole chromosome replication [PDF]

, 2010
All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S., de Moura, Alessandro Paula Servio, Retkute, Renata, Nieduszynski, Conrad A., Hawkins, Michelle   +4 more
core   +1 more source

Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia

, 2008
The intrachromosomal amplification of chromosome 21 (iAMP21) was identifiedas a novel and prognositically important acquired chromosomal abnormality inchildhood acute lymphoblastic leukaemia (ALL).
Robinson, Hazel M.
core   +1 more source

CHROMOSOMAL ABNORMALITIES IN A REFERRED POPULATION: A REPORT OF 383 IRANIAN CASES [PDF]

Acta Medica Iranica, 1998
This report presents the cytogenetic findings (G -banded chromosomal analysis} in 383 cases referred for suspected chromosomal abnormalities because of abnormal clinical features.
M. T. Akbari., F. Behjati., Ashtiani M. Khaleghian   +2 more
doaj   +1 more source

A rare case of mosaic partial tetrasomy 18p presenting with oligomenorrhea and intellectual disability: a case report

Frontiers in Medicine
BackgroundTetrasomy 18p syndrome is an extremely rare chromosomal disorder that is often the result of an additional isochromosome for the short arm of chromosome 18.
Guosheng Deng, Weiwu Liu, Yuqing Lai, Jinjie Pan, Yanyan Chen, Jujie Song, Donghua Zhang, Xiafei Liang, Sisi Ning, Yinghong Lu, Yunning Liang, Derong Li   +11 more
doaj   +1 more source

The Cytogenetics of the Water Buffalo: A Review

Animals, 2021
The water buffalo (Bubalus bubalis), also known as the Asian buffalo, is an essential domestic bovid. Indeed, although its world population (~209 million heads) is approximately one-ninth that of cattle, the management of this species involves a larger ...
Alessandra Iannuzzi, Pietro Parma, Leopoldo Iannuzzi   +2 more
doaj   +1 more source