Results 61 to 70 of about 409,247 (302)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Parallel derivation of X-monosomy induced pluripotent stem cells (iPSCs) with isogenic control iPSCs
Stem Cell Research, 2020 Turner syndrome, caused by partial or complete loss of one copy of X-chromosome (45,X), is the most common sex chromosome abnormality in women with an incidence of 1 in 2500 female births.
Anis Feki +2 more
doaj +1 more source
Chromosomal Abnormalities in Hypoprolific Boars [PDF]
Hereditas, 2004 Four new chromosomal rearrangements are reported in the domestic pig: 3 reciprocal translocations, rcp(4;12)(p13;q13) in a crossbred boar, rcp(1;7)(q17;q26) in a Large White purebred boar, rcp(1;6)(q17;q35) in a purebred synthetic paternal line boar, and a pericentric inversion inv(2)(p13q11) in a crossbred boar.
Pinton, Alain +8 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 2005 Interstitial deletion of the long arm of chromosome 20, as the sole abnormality, is commonly observed in myeloid malignancies, including myeloproliferative disorder, myelodysplastic syndrome, and acute myeloid leukemia.
Sivalingam, R +8 more
core +1 more source
Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]
, 1992 Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
Dunham, Ian +7 more
core +1 more source
IEEE Access, 2020 Chromosome analysis is an essential task in a cytogenetics lab, where cytogeneticists can diagnose whether there are abnormalities or not. Karyotyping is a standard technique in chromosome analysis that classifies metaphase image to 24 chromosome classes.
Mona Salem Al-Kharraz +2 more
doaj +1 more source
Increased nuchal translucency and fetal outcomes: a population-based study in Thailand
Clinical and Experimental Obstetrics & Gynecology, 2021 Background: To determine the association between increased nuchal translucency (INT) and fetal outcomes among Thai population. Methods: A prospective database of fetal Down syndrome screening project was accessed to enable retrieval of the records of any
Kuntharee Traisrisilp +7 more
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Cytogenetic characterization of Sambalpuri and Manda buffaloes of Odisha
Indian Journal of Animal Sciences, 2019 Cytogenetics analysis even though mostlyused for the evaluation of chromosomal abnormality by arresting the cell division at metaphase stage, but is also helpful to ascertain the riverine/swamp status of buffaloes. The study was conducted to characterize
LAVA KUMAR +6 more
doaj +1 more source