Results 161 to 170 of about 2,532,538 (409)
Chromosomes and causation of human cancer and leukemiaXXX. Banding studies of primary intestinal tumors [PDF]
, 1978 Shin‐ichi Sonta, Avery A. Sandberg
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Advanced Science, EarlyView.Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou +12 more
wiley +1 more source
Exploring the Multifractal Behavior of the Human Genome T2T-CHM13v2.0: Graphical Representations and Cytogenetics [PDF]
arXivIn this work, we applied the Chaos Game Representation (CGR) to the complete human genomic sequence T2T-CHM13v2.0, analyzing the entire chromosome assembly and each chromosome separately, including mitochondrial DNA. Multifractal spectra were determined using two types of box-counting coverage, revealing slight variations across most chromosomes. While
arxiv
Application of chromosome banding techniques to the study of primary chromosome structural changes. [PDF]
, 1977 John R. K. Savage
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Advanced Science, EarlyView.Different from mitosis, the female meiosis undergoes asymmetric division that produces haploid oocytes and polar body, which is essential for retaining maternal components to support subsequent fertilization and embryo development. However, the underlying mechanisms are still largely unknown.
Yu Li +6 more
wiley +1 more source
Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation
Advanced Science, EarlyView.The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu +8 more
wiley +1 more source
Simultaneous G and C banding of human chromosomes. [PDF]
, 1976 Luis M. de la Maza, O Sánchez
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A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
Advanced Science, EarlyView.The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye +21 more
wiley +1 more source
Excluded volume effect enhances the homology pairing of model chromosomes [PDF]
arXiv, 2015 To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a ...
arxiv
Advanced Science, EarlyView.Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia +8 more
wiley +1 more source