Results 161 to 170 of about 60,035 (243)
Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda +2 more
wiley +1 more source
ABSTRACT Background Nonobstructive azoospermia (NOA) is the most severe form of male infertility, with genetic factors contributing to approximately 30% of cases. However, only a small fraction of all NOA cases can be explained by the current genetic findings.
Ao Ma +12 more
wiley +1 more source
Abstract BACKGROUND Food additives are widely used to extend the shelf life of foods and maintain their quality. In this study, the potential of Prunus laurocerasus and Prunus cerasifera fruit pits (endocarp and seed) as food additives was investigated in terms of cytotoxicity, antigenotoxicity, antioxidant activity, enzymatic anti‐browning, and urease
Zühal Bayrakçeken Güven +4 more
wiley +1 more source
Natural and synthetic protoflavonoids offer potent anticancer properties, but their chemical space remains largely unexplored. This study details the synthesis of eleven p‐hydroxydienone derivatives from chalcone precursors. We evaluated their antiproliferative effects across four human gynecological cancer cell lines.
Tímea Gonda +7 more
wiley +1 more source
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
ABSTRACT This study aimed to investigate how maternal feed restriction at different gestational stages alters the expression of novel long non‐coding RNAs (lncRNAs) in the skeletal muscle of goat offspring. LncRNAs are emerging as important regulators of biological processes, including myogenesis, yet their role in fetal programming remains largely ...
Maria M. M. Muniz +8 more
wiley +1 more source
Cell Division: Single-Cell Physiology Reveals Secrets of Chromosome Condensation. [PDF]
Bloom K.
europepmc +1 more source
One thousand nine hundred sixty‐two genes associated with HCC TKI treatment responsiveness were identified through an internal unbiased genome‐wide CRISPR/Cas9 screening. A comprehensive HCC TKI treatment response landscape was constructed by integrating 20 datasets comprising a total of 322 TKI‐treated or TKI‐resistant HCC samples.
Si‐Yu Chen +10 more
wiley +1 more source
Detecting Chromosome Condensation Defects in Gulf War Illness Patients. [PDF]
Liu G +6 more
europepmc +1 more source
ABSTRACT Purpose To investigate the expression profile of IL‐6 in patients with acute promyelocytic leukemia (APL) and its role in modulating the ability of hPMSCs to regulate the differentiation of NB4 cells. Methods Peripheral blood samples were obtained from newly diagnosed APL patients and healthy controls.
Rong Qi +4 more
wiley +1 more source

