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Induction of prematurely condensed chromosomes by mitoplasts
Cell Biology International Reports, 1980The objective of this study was to obtain pure prematurely condensed chromosomes (PCC) by a fusion between mitoplasts and interphase G1 cells. The stabilization of mitoplasts with spermine (25 microM) and a modification of the Sendai virus-mediated fusion enabled us to obtain pure PCC without contaminating mitotic chromosomes.
P S, Sunkara +3 more
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Fragile X chromosome and chromosome condensation.
Annales de genetique, 1984The effect of chromosome condensation on the frequency of expression of the fragile X chromosome was examined. Chromosome decondensation substances were tested for their ability to elicit expression or improve frequencies of expression of the fragile X chromosome in five patients.
P B, Jacky, F J, Dill
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The role of DNA replication in chromosome condensation
BioEssays, 2002AbstractAt metaphase, DNA in a human chromosome is estimated to be compacted at least 10,000 fold in length.1,2 However, the higher order mechanisms by which the chromosomes are organized in interphase and subsequently further condensed in mitosis have largely remained elusive.
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Differentiating Chromosome Fragmentation and Premature Chromosome Condensation
2013The chromosome has long been viewed as a structure that ensures faithful segregation of the genetic materials to daughter cells. However, it is now apparent that the chromosome plays a central role in defining the genetic network through the genome context.
Joshua B. Stevens, Henry H. Q. Heng
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Gene controlled condensation in individual chromosomes
Experientia, 1982When cell were irradiated with variable doses of gamma rays, 0.33% showed the appearance of single decondensed chromosomes (SDC) at the moment at which all the other chromosomes of the complement exhibited the normal condensed state corresponding to metaphase stages. Several hypotheses are discussed to explain the origin of SDC.
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