Results 51 to 60 of about 60,035 (243)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology

Вавиловский журнал генетики и селекции
One of the most productive strategies for finding the functions of proteins is to study the consequences of loss of protein function. For this purpose, cells or organisms with a knockout of the gene encoding the protein of interest are obtained. However,
A. M. Yunusova, A. V. Smirnov, I. E. Pristyazhnuk, T. A. Shnaider, E. K. Maltseva, S. D.  Afonnikova, O. A. Gusev, N.  R. Battulin   +7 more
doaj   +1 more source

Evidence of activity-specific, radial organization of mitotic chromosomes in Drosophila. [PDF]

PLoS Biology, 2011
The organization and the mechanisms of condensation of mitotic chromosomes remain unsolved despite many decades of efforts. The lack of resolution, tight compaction, and the absence of function-specific chromatin labels have been the key technical ...
Yuri G Strukov, Tûba H Sural, Mitzi I Kuroda, John W Sedat   +3 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Мейотична мутація томату, що порушує конденсацію хроматину

Фактори експериментальної еволюції організмів, 2014
Aims. This paper presents the results of cytological and genetic analysis of new meiotic mutant of tomato (Lycopersicon esculentum Mill.) sti. Methods.
Т. П. Лісовська, І. І. Кузьмішина, Л. О. Коцун, В. П. Войтюк, В. В. Андреєва   +4 more
doaj  

A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex.

PLoS Genetics, 2015
The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3.
Ola Orgil, Avi Matityahu, Thomas Eng, Vincent Guacci, Douglas Koshland, Itay Onn   +5 more
doaj   +1 more source

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos

Cell Reports, 2015
During cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Remi Sonneville, Gillian Craig, Karim Labib, Anton Gartner, J. Julian Blow   +4 more
doaj   +1 more source

Prematurely condensed chromosomes of the Indian muntjac: A model system for the analysis of chromosome condensation and banding [PDF]

Hereditas, 2009
Premature chromosome condensation, PCC, was induced in interphase cells of the Indian muntjac (Muntiacus muntjak), by fusion with mitotic Lu106 (human) or muntjac cells, using inactivated Sendai virus. The G1 and G2 chromosomes appeared as single-respectively double-structured threads of variable length.
openaire   +2 more sources

Premature chromosome condensation in human leukemia [PDF]

Blood, 1976
Premature chromosome condensation (PCC) has previously been observed in tissue culture and is believed to arise from asynchronous mitotic activity in multinucleated cells in which the affected nucleus is in interphase and at least one nucleus is in metaphase.
D M, Williams, C D, Scott, T M, Beck
openaire   +3 more sources