Results 181 to 190 of about 30,958 (250)

Transcriptome and metabolome profiling uncover phenotypic divergence of gigantic and dwarf mutant genotypes in induced Pakchoi autotetraploids. [PDF]

BMC Plant Biol
Tang W, Zheng J, Sun C, Pan Q.
europepmc   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

A two-stage screening approach integrated with GWAS for rare phenotypes such as spontaneous haploid genome doubling in maize. [PDF]

Front Plant Sci
Fakude M, Foster TL, Chen YR, Murithi A, Aboobucker SI, Frei UK, Dixon PM, Lübberstedt T.   +7 more
europepmc   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma. [PDF]

Endocr Pathol
Backman S, Axling F, Zhang L, Botling J, Juhlin CC, Barazeghi E, Skogseid B, Klimácek B, Annebäck M, Zedenius J, Norlén O, Stålberg P, Crona J, Åkerström T.   +13 more
europepmc   +1 more source

Any old Tom, Dick, or Harry: The citation impact of author first name genderedness

Journal of the Association for Information Science and Technology, EarlyView.
Abstract This paper examines the relationship between the genderedness of authors' first names and citation distributions in US‐affiliated scholarly production from 2010 to 2019. Merging a first name genderedness table derived from Wikidata with Web of Science publication data, we develop a relative distributional framework that compares first name ...
Maxime Holmberg Sainte‐Marie, Vincent Larivière   +1 more
wiley   +1 more source

Covariate-adjusted AP-1 motif architecture and footprinting track olaparib-adaptive chromatin remodelling. [PDF]

Front Syst Biol
Dutta S.
europepmc   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Physiological temperature enhances proliferative capacity and protein production characteristics of chick satellite cells. [PDF]

Food Sci Anim Resour
Kim DB, Lee HJ, Lee HW, Jang HG, Oh SH, Kim JH, Lee SY.   +6 more
europepmc   +1 more source