Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Richter's syndrome with identification of marker chromosomes [PDF]
Cancer, 1980 A case is presented of a man with Richter's syndrome with diffuse histiocytic lymphoma following a ten-year history of untreated chronic lymphatic leukemia. He did not respond to therapy. The lymphoma cells had 61 chromosomes with aneuploidy of 13 chromosomes and 11 structurally altered chromosomes.
P H, Fitzgerald +3 more
openaire +2 more sources
Is the Y chromosome disappearing?—Both sides of the argument [PDF]
, 2011 On August 31, 2011 at the 18th International Chromosome Conference in Manchester, Jenny Graves took on Jenn Hughes to debate the demise (or otherwise) of the mammalian Y chromosome.
Darren K. Griffin, Griffin, Darren K.
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Identification and characterization of karyotype in Passiflora hybrids using FISH and GISH
BMC Genetics, 2018 Background A great interest exists in the production of hybrid plants of the genus Passiflora given the beauty and exotic features of its flowers which have ornamental value.
Gonçalo Santos Silva +4 more
doaj +1 more source
Cytological and molecular characterization of wheat lines with Thinopyrum intermedium chromosome additions, substitutions and translocations resistant to barley yellow dwarf virus [PDF]
, 1999 Barley yellow dwarf virus (BYDV) is the most serious viral disease affecting wheat and genes for BYDV resistance have not been found in wheat. BYDV-resistant alien addition and alien substitution lines produced from a wheat × Thinopyrum intermedium ...
Gyulai, Gábor +5 more
core
Differences of size and shape of active and inactive X-chromosome domains in human amniotic fluid cell nuclei [PDF]
, 1993 It is a widely held belief that the inactive X-chromosome (Xi) in female cell nuclei is strongly condensed as compared to the largely decondensed active X-chromosome (Xa).
Cremer, Thomas +11 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Karyotype characterization and evolution of chromosome number in Cactaceae with special emphasis on subfamily Cactoideae [PDF]
Acta Botânica Brasílica, 2019 Cactaceae species are karyotypically well-known with x = 11 and chromosome number variation due mainly to polyploidization. However, both assumptions are based on descriptive observations without taking an evolutionary framework of Cactaceae into account.
Juliana P. Castro +5 more
doaj +1 more source