Results 211 to 220 of about 194,576 (309)

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

Genomic map of the functionally extinct northern white rhinoceros (<i>Ceratotherium simum cottoni</i>). [PDF]

Proc Natl Acad Sci U S A
Wang G, Korody ML, Brändl B, Hernandez-Toro CJ, Rohrandt C, Hong K, Pang AWC, Lee J, Migliorelli G, Stanke M, Ford SM, Pollmann I, Houck ML, Lewin HA, Lear TL, Ryder OA, Meissner A, Loring JF, Müller FJ.   +18 more
europepmc   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

Combined Analysis of BSA-Seq and RNA-Seq Reveals Candidate Genes for <i>qGS1</i> Related to Sorghum Grain Size. [PDF]

Plants (Basel)
Shen Q, Wang K, Hu L, Li L, Wang L, Wang Y, Wang YH, Li J.   +7 more
europepmc   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Genetic dissection of hundred-kernel weight through combined genome-wide association study and linkage analysis in tropical maize. [PDF]

BMC Genomics
Shi M, Jiang F, Shaw RK, Ijaz B, Sun J, Fan X.   +5 more
europepmc   +1 more source

Isolation and mapping of a polymorphic DNA sequence (CJ52.27) on chromosome 16 [D16S149]

, 1989
Cécile Julier, Yusuke Nakamura, G.M. Lathrop, J.-M. Lalouel, R. White   +4 more
openalex   +2 more sources

Single‐Cell RNA Sequencing Identifies MMP11+ Cancer‐Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression

Advanced Science, EarlyView.
Single‐cell RNA sequencing identifies MMP11⁺ CAFs as pro‐angiogenic cells accumulating during bladder cancer progression. These cells promote angiogenesis by regulating ESM1⁺ tip endothelial cells and recruiting SPP1⁺ macrophages. Tumor‐derived BMP2 promotes their activation.
Wuwu Xu, Ting Liang, Hu Fang, Lu Fu, Dashi Deng, Xiyang Tan, Lisha Liu, Dongdong Tang, Haoxiang Zheng, Qiuxia Ding, Xiuqi Hou, Daquan Feng, Tao Tao, Song Wu   +13 more
wiley   +1 more source

Genetic Mapping of QTL Associated with 100-Kernel Weight Using a DH Population in Maize. [PDF]

Plants (Basel)
Li H, Li H, Chen J, Zhang X, Wang B, Zhi S, Guan H, Song W, Lai J, Zhao H, Gao R.   +10 more
europepmc   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source