Results 271 to 280 of about 2,043,269 (377)

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +8 more
wiley   +1 more source

RET@Thirty: the story behind identification of RET mutation as the cause of MEN2 and what it meant to clinical practice. [PDF]

Endocr Relat Cancer
Ponder B, Kurzawinski TR.
europepmc   +1 more source

Human type VII collagen: cDNA cloning and chromosomal mapping of the gene.

, 1991
M G Parente, L C Chung, J Ryynänen, David T. Woodley, Kimberly C Wynn, Eugene A. Bauer, Marie‐Geneviève Mattéi, Mon‐Li Chu, Jouni Uitto   +8 more
openalex   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Corrigendum: Saturation mapping of a major effect QTL for stripe rust resistance on wheat chromosome 2B in cultivar Napo 63 using SNP genotyping arrays. [PDF]

Front Plant Sci
Wu J, Wang Q, Liu S, Huang S, Mu J, Zeng Q, Huang L, Han D, Kang Z.   +8 more
europepmc   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Genome assemblies of Nuttall's White-crowned sparrow (Zonotrichia leucophrys nuttalli) and Rufous-collared sparrow (Zonotrichia capensis). [PDF]

Sci Data
Wu Z, Miedzinska K, Krause JS, Gonzalez-Gomez PL, Pérez JH, Wingfield JC, Meddle SL, Smith J.   +7 more
europepmc   +1 more source

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

Advanced Science, EarlyView.
This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng, Zhenhao Li, Weican Luo, Hongwu Chen, Tingting Deng, Zhenqi Gong, Qing Zheng, Baizhi Li, Yongming Zeng, Huaiming Wang, Cong Huang   +10 more
wiley   +1 more source

Chromosomal-level genome assembly of Trichogramma dendrolimi (Trichogrammatidae: Hymenoptera). [PDF]

Sci Data
Dong Q, Dong Z, Ning S, Li G, Che W, Fang G, Zhan S, Zhou J, Dong H.   +8 more
europepmc   +1 more source

scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready

Advanced Science, EarlyView.
scCompass integrates and standardizes transcriptomic data from ≈105 million single cells across 13 species, enabling the identification of stable expression genes and organ‐specific expression genes in humans and mice. It provides scalable datasets for AI model training, pretrained model checkpoints, and user‐friendly platforms for data sharing ...
Pengfei Wang, Wenhao Liu, Jiajia Wang, Yana Liu, Pengjiang Li, Ping Xu, Wentao Cui, Ran Zhang, Qingqing Long, Zhilong Hu, Chen Fang, Jingxi Dong, Chunyang Zhang, Yan Chen, Chengrui Wang, Guole Liu, Hanyu Xie, Yiyang Zhang, Meng Xiao, Shubai Chen, Haiping Jiang, The X‐Compass Consortium, Yiqiang Chen, Ge Yang, Shihua Zhang, Zhen Meng, Xuezhi Wang, Guihai Feng, Xin Li, Yuanchun Zhou   +29 more
wiley   +1 more source