Results 81 to 90 of about 2,184,990 (399)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Linkage Variation and Chromosome Maps [PDF]

open access: yesProceedings of the National Academy of Sciences, 1921
A recent paper in this journal by Detlefsen(1) is introduced as follows: "There is a well intrenched concept of recent genetics that hereditary factors or genes may be given fairly definite loci on chromosome maps and that these maps correspond to or represent, roughly perhaps, the actual conditions in the chromosome.
openaire   +3 more sources

Chromosome mapping in Pseudomonas aeruginosa.

open access: yesGenetical research, 1972
A more extensive linkage map of Pseudomonas aeruginosa strain PAO has been compiled from data obtained by both conjugation and transduction procedures. All the markers examined are located on one linkage group and the available evidence suggests that the
J. M. Pemberton, B. Holloway
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

GENETICS AND GENOMICS OF PLANT GENETIC RESOURCES [PDF]

open access: yesJournal of Stress Physiology & Biochemistry, 2012
Plant genetic resources play a major role for global food security. The most significant and widespread mean of conserving plant genetic resources is ex situ conservation.
Börner A.   +11 more
doaj  

Genetic algorithms for auto-tuning mobile robot motion control [PDF]

open access: yes, 2002
This paper discusses a genetic algorithm (GA) based method for automatically tuning mobile robot motion controllers. The genetic algorithm evolves a controller that is optimised for a given performance measure. Genetic algorithms require a mapping from
Messom, Chris
core  

A universal method for automated gene mapping [PDF]

open access: yes, 2005
Small insertions or deletions (InDels) constitute a ubiquituous class of sequence polymorphisms found in eukaryotic genomes. Here, we present an automated high-throughput genotyping method that relies on the detection of fragment-length polymorphisms ...
Basler, Konrad   +6 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Common Wheat Chromosome 5B Composition Analysis Using Low-Coverage 454 Sequencing

open access: yesThe Plant Genome, 2014
The sequencing of individual chromosomes of common wheat is in progress. The molecular size of wheat chromosome 5B is nearly 870 Mb (5BL = 580 Mb and 5BS = 290 Mb).
E. M. Sergeeva   +11 more
doaj   +1 more source

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