Results 31 to 40 of about 4,074,715 (354)

Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage

Nature Communications, 2022
During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via ...
Stéphanie Durand, Qichao Lian, Juli Jing, Marcel Ernst, Mathilde Grelon, David Zwicker, Raphael Mercier   +6 more
doaj   +1 more source

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice

Scientific Reports, 2021
Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals.
Satoshi Abe, Kazuhisa Honma, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi, Yuji Nakayama, Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki   +13 more
doaj   +1 more source

Condensin-mediated chromosome organization in fission yeast. [PDF]

Curr Genet, 2016
Iwasaki O, Noma KI.
europepmc   +2 more sources

Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

Nature Communications, 2023
DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to ...
Wei Wu, Szymon A. Barwacz, Rahul Bhowmick, Katrine Lundgaard, Marisa M. Gonçalves Dinis, Malgorzata Clausen, Masato T. Kanemaki, Ying Liu   +7 more
doaj   +1 more source

Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector

Pharmaceuticals, 2020
Conditional degron-based methods are powerful for studying protein function because a degron-fused protein can be rapidly and efficiently depleted by adding a defined ligand.
Aisha Yesbolatova, Yuichiro Saito, Masato T. Kanemaki   +2 more
doaj   +1 more source

Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.

Mol Cell, 2017
Diebold-Durand ML, Lee H, Ruiz Avila LB, Noh H, Shin HC, Im H, Bock FP, Bürmann F, Durand A, Basfeld A, Ham S, Basquin J, Oh BH, Gruber S.   +13 more
europepmc   +2 more sources

MukBEF, a Chromosomal Organizer [PDF]

Microbial Physiology, 2014
Global folding of bacterial chromosome requires the activity of condensins. These highly conserved proteins are involved in various aspects of higher-order chromatin dynamics in a diverse range of organisms. Two distinct superfamilies of condensins have been identified in bacteria.
Valentin V. Rybenkov, Zoya M. Petrushenko, Hang Zhao, Viridiana Herrera   +3 more
openaire   +3 more sources

Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci

Nature Communications, 2022
Trans-chromosomic (Tc) mice have helped the development of therapeutic antibodies, but chromosome instability limits its application. Here the authors develop a new line of Tc mice with full human Ig heavy and kappa loci integrated into the mouse ...
Hiroyuki Satofuka, Satoshi Abe, Takashi Moriwaki, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Kyotaro Yamazaki, Genki Hichiwa, Kayoko Morimoto, Haruka Takayama, Yuji Nakayama, Shinya Hatano, Yutaro Yada, Yasufumi Murakami, Yoshihiro Baba, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki   +17 more
doaj   +1 more source

Chromosomal Organization: Mingling with the Neighbors [PDF]

PLoS Biology, 2006
Jacob Aten and Roland Kanaar highlight recent advances in understanding the physical organization of chromosomes in the nucleus.
Jacob A. Aten, Roland Kanaar
openaire   +5 more sources

Genome Copy Number Quantification Revealed That the Ethanologenic Alpha-Proteobacterium Zymomonas mobilis Is Polyploid

Frontiers in Microbiology, 2021
The alpha-proteobacterium Zymomonas mobilis is a promising biofuel producer, based on its native metabolism that efficiently converts sugars to ethanol. Therefore, it has a high potential for industrial-scale biofuel production.
Katsuya Fuchino, Katsuya Fuchino, Daniel Wasser, Jörg Soppa   +3 more
doaj   +1 more source