Results 51 to 60 of about 405,684 (326)

Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy) [PDF]

, 2018
The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis.
Eliana Ayarza, Emanuela Solano, Ernesto Capanna, Jesús Page, Raúl Fernández-Donoso, Riccardo Castiglia, Soledad Berríos   +6 more
core   +3 more sources

Genome Organization Drives Chromosome Fragility [PDF]

Cell, 2017
In this study, we show that evolutionarily conserved chromosome loop anchors bound by CCCTC-binding factor (CTCF) and cohesin are vulnerable to DNA double strand breaks (DSBs) mediated by topoisomerase 2B (TOP2B). Polymorphisms in the genome that redistribute CTCF/cohesin occupancy rewire DNA cleavage sites to novel loop anchors.
Andres, Canela, Yaakov, Maman, Seolkyoung, Jung, Nancy, Wong, Elsa, Callen, Amanda, Day, Kyong-Rim, Kieffer-Kwon, Aleksandra, Pekowska, Hongliang, Zhang, Suhas S P, Rao, Su-Chen, Huang, Peter J, Mckinnon, Peter D, Aplan, Yves, Pommier, Erez Lieberman, Aiden, Rafael, Casellas, André, Nussenzweig   +16 more
openaire   +2 more sources

Chromosome mapping of dragline silk genes in the genomes of widow spiders (araneae, theridiidae) [PDF]

, 2010
With its incredible strength and toughness, spider dragline silk is widely lauded for its impressive material properties. Dragline silk is composed of two structural proteins, MaSp1 and MaSp2, which are encoded by members of the spidroin gene family ...
Ayoub, NA, Hayashi, CY, Zhao, Y
core   +7 more sources

The dynamic three-dimensional organization of the diploid yeast genome

eLife, 2017
The budding yeast Saccharomyces cerevisiae is a long-standing model for the three-dimensional organization of eukaryotic genomes. However, even in this well-studied model, it is unclear how homolog pairing in diploids or environmental conditions ...
Seungsoo Kim, Ivan Liachko, Donna G Brickner, Kate Cook, William S Noble, Jason H Brickner, Jay Shendure, Maitreya J Dunham   +7 more
doaj   +1 more source

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]

, 2012
The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean, Bau, Bau, Bender, Bender, Botta, Chunhui Hou, Cook, Cui, de Gennes, Dekker, Dorier, Dostie, Drissen, Duan, Farrell, François Képès, Fraser, Hadjur, Handoko, Hou, Hou, Ivan Junier, Junier, Kalhor, Kiefer, Kim, Krivega, Kurukuti, Langowski, Lee, Lieberman-Aiden, Marenduzzo, Mateos-Langerak, Mukhopadhyay, Murrell, Ong, Palstra, Phillips, Ragoczy, Reuillon, Rosa, Rousseau, Ryan K. Dale, Schoenfelder, Sexton, Sexton, Simonis, Song, Song, Splinter, Stamatoyannopoulos, Strick, Tolhuis, Vakoc, Wallace, Yaffe   +56 more
core   +6 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations

Frontiers in Microbiology, 2018
Model bacteria, such as E. coli and B. subtilis, tightly regulate cell cycle progression to achieve consistent cell size distributions and replication dynamics. Many of the hallmark features of these model bacteria, including lateral cell wall elongation
Michelle M. Logsdon, Michelle M. Logsdon, Bree B. Aldridge, Bree B. Aldridge, Bree B. Aldridge   +4 more
doaj   +1 more source

Uncovering Proximity of Chromosome Territories using Classical Algebraic Statistics [PDF]

, 2014
Exchange type chromosome aberrations (ETCAs) are rearrangements of the genome that occur when chromosomes break and the resulting fragments rejoin with other fragments from other chromosomes.
Arsuaga, Javier, Heskia, Ido, Hosten, Serkan, Maskalevich, Tatsiana   +3 more
core  

Immunocytochemical localization of chromatin regions UV-microirradiated in S phase or anaphase : Evidence for a territorial organization of chromosomes during cell cycle of cultured Chinese hamster cells [PDF]

, 1983
Chinese hamster cells (M3-1 line) in S phase were laser-UV-microirradiated (λ, 257 nm) at a small site of the nucleus. Cells were fixed either immediately thereafter or in subsequent stages of the cell cycle, including prophase and metaphase.
Avivi, Bennett, Berns, Boveri, Boveri, Comings, Cornelis, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Earnshaw, Gray, Hager, Hancock, Hancock, Hens, Laemmli, Rabl, Regan, Sakharov, Sedat, Sperling, Stack, Trosko, Vogel, Zorn   +33 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source