Results 91 to 100 of about 841,598 (254)

Unified theory of human genome reveals a constrained spatial chromosomal arrangement in interphase nuclei [PDF]

, 2015
We investigate a densely packed, non-random arrangement of forty-six chromosomes (46,XY) in human nuclei. Here, we model systems-level chromosomal crosstalk by unifying intrinsic parameters (chromosomal length and number of genes) across all pairs of chromosomes in the genome to derive an extrinsic parameter called effective gene density.
arxiv   +1 more source

Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]

, 2003
The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J., Jentsch, I., Klein, C. A., Speicher, M. R.   +3 more
core   +1 more source

Placing women in Cytogenetics: Lore Zech and the chromosome banding technique

Molecular Cytogenetics, 2021
Background Scholars agree that Torbjörn Caspersson’s lab at the Institute of Medical Cell Research and Genetics at the Karolinska Institute, Sweden, played a key role in the first description of the so-called Q-banding technique.
Felicitas Söhner, Nils Hansson
doaj   +1 more source

Catastrophic chromosomal restructuring during genome elimination in plants. [PDF]

, 2015
Genome instability is associated with mitotic errors and cancer. This phenomenon can lead to deleterious rearrangements, but also genetic novelty, and many questions regarding its genesis, fate and evolutionary role remain unanswered.
Bradnam, Keith R, Chan, Simon Wl, Comai, Luca, Henry, Isabelle M, Korf, Ian, Lysak, Martin A, Mandakova, Terezie, Marimuthu, Mohan Pa, Ravi, Maruthachalam, Tan, Ek Han   +9 more
core   +1 more source

Chromosome painting in the manatee supports Afrotheria and Paenungulata

BMC Evolutionary Biology, 2007
Background Sirenia (manatees, dugongs and Stellar's sea cow) have no evolutionary relationship with other marine mammals, despite similarities in adaptations and body shape.
Zori Roberto T, McGuire Peter M, Gray Brian A, Stone Gary, Dennis Thomas R, Burkett Sandra, Kellogg Margaret E, Stanyon Roscoe   +7 more
doaj   +1 more source

Specific metaphase and interphase detection of the breakpoint region in 8q24 of burkitt lymphoma cells by triple-color fluorescence in situ hybridization [PDF]

, 1992
Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line Jl was used for the specific delineation of ...
Anastasi, Arnoldus, Baldini, Bornkamm, Cremer, Cremer, Cremer, Cremer, Crescenzi, Devilee, Emmerich, Hartl, Heim, Henglein, Hopman, Hopman, Klobeck, Kolluri, Lee, Lengauer, Lengauer, Lichter, Lichter, Lichter, Maniatis, Manolov, Nederlof, Nederlof, Pinkel, Rappold, Tkachuk, Walt, Wiegant, Zech   +33 more
core   +1 more source

Microdissection and Chromosome Painting

, 2015
The principle of chromosome microdissection technique is based on the identification of either a chromosome, chromosome arm or chromosome band for the subsequent removal of such target with the aid of a micromanipulator attached to an inverted microscope. Once the target is defined, whole chromosomes, or chromosomal regions, are directly isolated under
Vicari, M. R., Pansonato-Alves, J. C., Foresti, F.   +2 more
openaire   +2 more sources

Observations on chromosome-specific sequencing for the construction of cross-species chromosome homology maps and its resolution of human:alpaca homology

Molecular Cytogenetics, 2022
Background The history of comparative chromosome mapping is briefly reviewed, with discussion about the problem that occurs in chromosome painting when size heteromorphisms between homologues cause contamination in chromosomes sorted by flow cytometry ...
Malcolm A. Ferguson-Smith, Jorge C. Pereira, Ana Borges, Fumio Kasai   +3 more
doaj   +1 more source

Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21 [PDF]

, 1992
A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2.
Becher, Reinhard, Cremer, Thomas, Green, Eric D., Konecki, David, Lengauer, Christoph, Olson, Maynard V., Riethman, Harold C., Speicher, Michael R., Taniwaki, Masafumi   +8 more
core  

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
A Henderson, A Hill, A Krystosek, A Smogorzewska, AH Sturtevant, AK Sinha, AL Lam, Anna Jauch, AW Higgins, AW Higgins, AW Lo, B McClintock, B van Steensel, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BE Black, BE Black, Beth A. Sullivan, C Mann, C Pondarre, C Shiels, C Tyler-Smith, CH Gravholt, D Granick, D Hanahan, D Koshland, DJ Wolff, DK Palmer, DK Palmer, DR Foltz, DR Foltz, E Novitski, E Therman, EM Dunleavy, F Han, F Mitelman, F Mitelman, F Mitelman, GB Celli, GM Greig, Gregory P. Copenhaver, HE Trowell, Heidi Holtgreve-Grez, HF Willard, Ihn Young Song, J Hamerton, J Karlseder, J Karlseder, J Lange, J Pampalona, J Waye, JA Brock, JA Croft, JA Evans, JA Hackett, JE Sylvester, JJ Roix, JM Bridger, JM Craig, JM Spence, Joanna M. Bridger, K Ahmad, K Bross, K Mizuno, Kaitlin M. Stimpson, Karen E. Hayden, KH Choo, M Krzywinski, MD Blower, MD Blower, MG Schueler, MJ Ramirez, MR Branco, MR Lowden, NC Steiner, P Maraschio, PB Vagnarelli, PE Warburton, PE Warburton, S Cardinale, S Schwartz, S Spadari, S Zhang, SF Louis, SL Page, T Dousset, T Haaf, T Hori, TC Hsu, W Robertson, WC Earnshaw, WC Earnshaw, XY Guan, YZ Zheng   +96 more
core   +4 more sources