Results 171 to 180 of about 38,555 (288)

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene

open access: yesAdvanced Science, EarlyView.
Exposure to PTFE (teflon), a commonly used microplastic in non‐stick cookware, significantly reduces sperm quality in both humans and mice. Specifically, PTFE induces the disruption of sperm cytoskeleton and F‐actin assembly through targeting SKAP2 in haploid spermatid.
Shiming Gan   +15 more
wiley   +1 more source

MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice [PDF]

open access: gold, 2000
Burkhard Kneitz   +9 more
openalex   +1 more source

GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds

open access: yesAdvanced Science, EarlyView.
This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng   +17 more
wiley   +1 more source

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

open access: yesAdvanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho   +12 more
wiley   +1 more source

Suppressed Recombination and a Pairing Anomaly on the Mating-Type Chromosome of Neurospora tetrasperma [PDF]

open access: bronze, 2000
Alena M. Gallegos   +4 more
openalex   +1 more source

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