Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease
Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira+10 more
wiley +1 more source
Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex
The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved+5 more
wiley +2 more sources
Structural basis for C. elegans pairing center DNA binding specificity by the ZIM/HIM-8 family proteins. [PDF]
Li M+15 more
europepmc +1 more source
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska+2 more
wiley +1 more source
Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo-painting in cucumber. [PDF]
Zhao Q+7 more
europepmc +1 more source
A wide range of chromosome numbers result from unreduced gamete production in Brassica juncea × B. napus (AABC) interspecific hybrids. [PDF]
Addo Nyarko C+4 more
europepmc +1 more source
FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes. [PDF]
Ma A, Yang Y, Cao L, Chen L, Zhang JV.
europepmc +1 more source
Optical Probes for Cellular Imaging of G‐quadruplexes: Beyond Fluorescence Intensity Probes
The study of G‐quadruplex (G4) structures that form in DNA and RNA is a rapidly growing field, which has evolved from in vitro studies of isolated G4 sequences to genome‐wide detection of G4s in a cellular context. This work has revealed the tangible and significant effects that G4s may have on biological regulation.
Jenna Robinson+3 more
wiley +1 more source
Checkpoints: Chromosome pairing takes an unexpected twist
Bettina Meier, Shawn Ahmed
openalex +2 more sources