Results 281 to 290 of about 199,391 (364)

A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

open access: gold, 2001
Paweł Pasierbek   +5 more
openalex   +1 more source

Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease

open access: yesAnnals of Neurology, EarlyView.
Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira   +10 more
wiley   +1 more source

Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex

open access: yesAngewandte Chemie, EarlyView.
The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved   +5 more
wiley   +2 more sources

Structural basis for C. elegans pairing center DNA binding specificity by the ZIM/HIM-8 family proteins. [PDF]

open access: yesNat Commun
Li M   +15 more
europepmc   +1 more source

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

open access: yesAdvanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska   +2 more
wiley   +1 more source

Optical Probes for Cellular Imaging of G‐quadruplexes: Beyond Fluorescence Intensity Probes

open access: yesAngewandte Chemie International Edition, Accepted Article.
The study of G‐quadruplex (G4) structures that form in DNA and RNA is a rapidly growing field, which has evolved from in vitro studies of isolated G4 sequences to genome‐wide detection of G4s in a cellular context. This work has revealed the tangible and significant effects that G4s may have on biological regulation.
Jenna Robinson   +3 more
wiley   +1 more source

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