Results 1 to 10 of about 455,442 (295)
An intelligent recognition method of chromosome rearrangement patterns based on information entropy [PDF]
Scientific Reports, 2022 Chromosome rearrangements play an important role in the speciation of plants and animals, and the recognition of chromosome rearrangement patterns is helpful to elucidate the mechanism of species differentiation at the chromosome level.
Fushun Wang +6 more
doaj +2 more sources
Clinical and Genetic Analysis of Pediatric Neurodevelopmental Disorders With Complex Chromosomal Rearrangements in Two Cases [PDF]
Molecular Genetics & Genomic MedicineObjective Our study investigates the impact of junction breakpoints of complex chromosomal rearrangements (CCRs) on developmental delay and intermittent epilepsy in children, aiming to elucidate the underlying genetic mechanisms.
Jiaci Li +6 more
doaj +2 more sources
mSystems, 2019 Whooping cough (pertussis), primarily caused by Bordetella pertussis, has resurged in the United States, and circulating strains exhibit considerable chromosome structural fluidity in the form of rearrangement and deletion.
Michael R. Weigand +14 more
doaj +3 more sources
Engineering chromosome rearrangements in cancer [PDF]
Disease Models & Mechanisms, 2021 ABSTRACT The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in ...
Salvador Alonso, Lukas E. Dow
openaire +3 more sources
Gross Chromosomal Rearrangement at Centromeres
Biomolecules, 2023 Centromeres play essential roles in the faithful segregation of chromosomes. CENP-A, the centromere-specific histone H3 variant, and heterochromatin characterized by di- or tri-methylation of histone H3 9th lysine (H3K9) are the hallmarks of centromere chromatin.
Ran Xu, Ziyi Pan, Takuro Nakagawa
openaire +3 more sources
Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
Nature Communications, 2021 Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al.
Virginia S. Lioy +17 more
doaj +1 more source
Molecular Dissection Using Array Comparative Genomic Hybridization and Clinical Evaluation of An Infertile Male Carrier of An Unbalanced Y;21 Translocation: A Case Report and Review of The Literature [PDF]
International Journal of Fertility and Sterility, 2016 Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported.
Alfredo Orrico +7 more
doaj +1 more source
Chromosome Rearrangements in Canine Fibrosarcomas [PDF]
Journal of Heredity, 2005 We have previously reported the use of six- and seven-color paint sets in the analysis of canine soft tissue sarcomas. Here we combine this technique with flow sorting of translocation chromosomes, reverse painting, and polymerase chain reaction (PCR) analysis of the gene content of the reverse paint in order to provide a more detailed analysis of ...
D R, Sargan +6 more
openaire +2 more sources
Molecular Cytogenetics, 2017 Background Neocentromeres are rare and considered chromosomal aberrations, because a non-centromeric region evolves in an active centromere by mutation.
N. Villa +7 more
doaj +1 more source
Stimulation of Chromosomal Rearrangements by Ribonucleotides [PDF]
Genetics, 2015 AbstractWe show by whole genome sequence analysis that loss of RNase H2 activity increases loss of heterozygosity (LOH) in Saccharomyces cerevisiae diploid strains harboring the pol2-M644G allele encoding a mutant version of DNA polymerase ε that increases ribonucleotide incorporation.
Hailey N, Conover +9 more
openaire +2 more sources