Results 131 to 140 of about 455,442 (295)

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

Philadelphia chromosome-like acute lymphoblastic leukemia with concomitant rearrangements of CRLF2 and ABL1: a pediatric case report

BMC Pediatrics
Background BCR::ABL1-like or Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) was first reported in 2009. Ph-like ALL is characterized by gene signature similar to Philadelphia chromosome ALL, but without BCR::ABL1 fusions ...
Guo-qian He, Yu-peng Lei, Duo-wen Huang, Ju Gao, Rong Yang   +4 more
doaj   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Sorghum T2T pangenome highlights comprehensive genomic variation

iMetaOmics, EarlyView.
Three newly assembled telomere‐to‐telomere (T2T) genomes representing wild, landrace, and transformable germplasm were integrated with seven publicly available T2T genomes to construct a graph‐based pangenome. Comparative analyses revealed extensive centromere divergence, including distinct CEN137 monomer and CEN274 dimer organization, and showed that ...
Lihua Wang, Chuanzheng Wei, Hope O. Okunbor, Xiaofei Deng, Die Hu, Yongfei Wang, Junli Du, Ephrem Habyarimana, Yongfu Tao, Yi‐Hong Wang, Jieqin Li   +10 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Reverse painting highlights the origin of chromosome aberrations

, 2004
Reverse chromosome painting, as the opposite of forward chromosome painting, means that an abnormal chromosome of interest is recovered by flow sorting or by chromosome microdissection, amplified and labelled by DOP-PCR and hybridized onto normal ...
Blennow, E
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Application of fluorescence in situ hybridization in defining a complex t(9;21;22) Ph formation

Haematologica, 1994
We describe the application of fluorescence in situ hybridization (FISH) in a case of suspected chronic myelogenous leukemia (CML), cytogenetically characterized by a t(21;22) with no clear involvement of chromosome 9.
M Mancini, M Nanni, M Cedrone, MR De Cuia, MB Rondinelli, F Malagnino, G Alimena   +6 more
doaj  

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

, 2006
Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome, mapping entirely to the distal half of mouse chromosome 11.
Searle, Steven,, O'Leary, Sinéad,, Humphray, Sean, Garber, Manuel, Goldstein, Steven, Matthews, Lucy, Bugalter, Boris,, Schwartz, David,, Kamal, Michael,, Hosage Norman, Catherine,, Osoegawa, Kazutoyo, Allen, Nicole R, Bloom, Toby, de Jong, Pieter J, Lokyitsang, Tashi, Dewar, Ken,, Gibson, Richard,, LaButti, Kurt, Cuomo, Christina A, Adams, David J, FitzGerald, Michael, O'Leary, Sinéad B, Hart, Elizabeth, Adams, David,, Shaw-Smith, Charles,, Borowsky, Mark L, Mihalev, Atanas H, Humphray, Sean,, Young, Sarah K, Jaffe, David,, Corum, Benjamin,, Loveland, Jane, Laird, Gavin,, Macdonald, Pendexter, Bradley, Allan,, Searle, Steven M, Chang, Jean L, Swarbreck, David,, Chang, Jean,, Wilming, Laurens,, Steward, Charles,, Grocock, Russell, Nusbaum, Chad,, Gilbert, James,, Garber, Manuel,, Mihalev, Atanas,, Gilbert, James, McCarroll, Steven A, Venkataraman, Vijay, Major, John,, Whittaker, Charles,, Steward, Charles, Major, John E, Mauceli, Evan, Lupski, James R, Macdonald, Pendexter,, Jones, Matt,, Bugalter, Boris E, Zody, Michael C, Norman, Catherine Hosage, Nguyen, Cindy,, Loveland, Jane,, Abouelleil, Amr,, Rogers, Jane, Hagopian, Daniel S, Liu, Xiaohong, Abouelleil, Amr, Cook, April, Nicol, Robert, Hubbard, Tim,, Allen, Nicole,, Mauceli, Evan,, Shaw-Smith, Charles, Nicol, Robert,, Mudge, Jonathan, Cook, April,, Hafez, Nabil,, Chen, Chao-Kung, DeCaprio, David, Khodiyar, Varsha K, Cuomo, Christina,, Harrow, Jennifer,, Sharpe, Ted,, Lehoczky, Jessica, Nguyen, Cindy, Osoegawa, Kazutoyo,, Swarbreck, David, Dewar, Ken, Liu, Xiaohong,, Wilming, Laurens, Lehoczky, Jessica,, Matthews, Lucy,, Yang, Xiaoping,, Bi, Weimin, Mudge, Jonathan,, Venkataraman, Vijay,, Rogers, Jane,, Bradley, Allan, Hagopian, Daniel,, Hubbard, Tim; id_orcid, Lui, Annie,, Lui, Annie, Schwartz, David C, Bloom, Toby,, Gnerre, Sante,, Laird, Gavin, Nicholson, Christine,, Sharpe, Ted, DeCaprio, David,, Jaffe, David B, Borowsky, Mark,, Zimmer, Andrew R, Goldstein, Steven,, Stankiewicz, Pawel,, Stankiewicz, Pawel, Gibson, Richard, Whittaker, Charles A, Lander, Eric S, Bi, Weimin,, Zody, Michael,, Nusbaum, Chad, LaButti, Kurt,, FitzGerald, Michael,, Young, Sarah,, Chen, Chao-Kung,, Hart, Elizabeth,, Lokyitsang, Tashi,, Grafham, Darren,, Gnerre, Sante, Grafham, Darren V, McCarroll, Steven,, Jones, Matt, Lander, Eric,, Nicholson, Christine, Birren, Bruce W, Butler, Jonathan,, Hafez, Nabil, Corum, Benjamin, de Jong, Pieter,, Grocock, Russell,, Kamal, Michael, Zimmer, Andrew,, Harrow, Jennifer, Birren, Bruce,, Butler, Jonathan, Yang, Xiaoping, Lupski, James,, Khodiyan, Varsha,   +147 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source