Results 211 to 220 of about 63,140 (263)

Chromosomal rearrangements and speciation

Trends in Ecology & Evolution, 2001
Several authors have proposed that speciation frequently occurs when a population becomes fixed for one or more chromosomal rearrangements that reduce fitness when they are heterozygous. This hypothesis has little theoretical support because mutations that cause a large reduction in fitness can be fixed through drift only in small, inbred populations ...
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Engineering chromosomal rearrangements in mice

Nature Reviews Genetics, 2001
The combination of gene-targeting techniques in mouse embryonic stem cells and the Cre/loxP site-specific recombination system has resulted in the emergence of chromosomal-engineering technology in mice. This advance has opened up new opportunities for modelling human diseases that are associated with chromosomal rearrangements.
Y, Yu, A, Bradley
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Rearrangements and chromosomal evolution

Current Opinion in Genetics & Development, 2003
Comparisons of the genome sequences of related species suggests varying patterns of chromosomal rearrangements in different evolutionary lineages. In this review, I focus on the quantitative characterization of rearrangement processes and discuss specific inventories that have been compiled to date.
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Rearrangements of chromosome 15 in epilepsy

American Journal of Medical Genetics, 2001
AbstractA number of observations point to chromosome 15 as a good candidate to harbor genes involved in epilepsy. This hypothesis is supported by at least two lines of evidence: one is the finding that haploinsufficiency of the 15q11‐q13 region, of maternal origin, is responsible for Angelman syndrome, one of the cardinal manifestations of which is ...
L, Torrisi, E, Sangiorgi, L, Russo, F, Gurrieri   +3 more
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A mathematical theory of chromosomal rearrangements

Journal of Genetics, 1947
A theory is given of the process of chromosomal structural rearrangement following irradiation. The theory applies to nuclei in which the union of breakage ends is at random, and assumes that the number of breaks primarily produced is proportional to the dose.
J B S, HALDANE, D E, LEA
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Chromosomal rearrangements in bladder cancer

Urology, 1984
Description des nouvelles techniques cytogenetiques d'etude des tumeurs solides des aberrations chromosomiques et des oncogenes dans les cellules cancereuses. Etude des rearrangements chromosomiques specifiques dans le cancer de la vessie et de l'importance pronostique du caryotype dans le cancer de la ...
Z, Gibas, A A, Sandberg
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Chromosome Rearrangements and Transposable Elements

Annual Review of Genetics, 2002
▪ Abstract  There has been limited corroboration to date for McClintock's vision of gene regulation by transposable elements (TEs), although her proposition on the origin of species by TE-induced complex chromosome reorganizations in combination with gene mutations, i.e., the involvement of both factors in relatively sudden formations of species in ...
Wolf-Ekkehard, Lonnig, Heinz, Saedler
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Chromosome rearrangements in trypanosoma brucei

Cell, 1984
We have studied chromosome rearrangements in T. brucei using pulsed field gradient gel electrophoresis to separate chromosome-sized DNA molecules. We detect size changes in a set of small chromosomes (200-700 kb) at a frequency of 10(-5) to 10(-6) per trypanosome division; this results in a radical difference in the size distribution of these ...
L H, Van der Ploeg, A W, Cornelissen, P A, Michels, P, Borst   +3 more
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Multiple chromosome rearrangements in a fibrosarcoma

Cancer Genetics and Cytogenetics, 1996
Clonal chromosome changes of a complex nature were found in a case of adult fibrosarcoma. Few studies on this tumor have been published, all showing complex changes without characteristic anomalies.
P, Dal Cin, P, Pauwels, R, Sciot, H, Van den Berghe   +3 more
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Chromosome rearrangements in Giardia lamblia

Parasitology Today, 1994
Recent studies have shown that the genome of Giardia lamblia is plastic. Clinical isolates exhibit extensive karyotypic heterogeneity and chromosome rearrangements occur frequently, in vitro. In this review, Sylvie Le Blancq looks at genome organization and the impact of DNA rearrangement events.
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