Results 271 to 280 of about 178,325 (322)

The spindle protein CKAP2 regulates microtubule dynamics and ensures faithful chromosome segregation. [PDF]

Proc Natl Acad Sci U S A
Paim LMG, Lopez-Jauregui AA, McAlear TS, Bechstedt S.   +3 more
europepmc   +1 more source

Mesenchymal stem cell‐mediated mitochondrial transfer regulates the fate of B lymphocytes

European Journal of Clinical Investigation, EarlyView.
Mesenchymal stem cells (MSCs) modulate immune responses by transferring mitochondria to immune cells, including B lymphocytes. This study demonstrates that mitochondrial transfer to CD19+ cells is linked to reactive oxygen species levels, mitophagy and activation. Mitochondria acquisition enhances B cell viability and proliferation while downregulating
Veronika Somova, Natalie Jaborova, Bianka Porubska, Daniel Vasek, Natalie Fikarova, Martin Prevorovsky, Zuzana Nahacka, Jiri Neuzil, Magdalena Krulova   +8 more
wiley   +1 more source

The chromatin-associated 53BP1 ortholog, HSR-9, regulates recombinational repair and X chromosome segregation in the Caenorhabditis elegans germ line. [PDF]

Genetics
Li Q, Hariri S, Calidas A, Kaur A, Huey E, Engebrecht J.   +5 more
europepmc   +1 more source

Clinical whole genome sequencing in pediatric epilepsy: Genetic and phenotypic spectrum of 733 individuals

Epilepsia, EarlyView.
Abstract Objective A large proportion of pediatric epilepsies have an underlying genetic etiology. Limited studies have explored the efficacy of whole genome sequencing (WGS) in a clinical setting. Our academic–clinical center implemented clinical whole exome sequencing (WES) in 2014, then transitioned to WGS from 2015.
Olivia J. Henry, Sofia Ygberg, Michela Barbaro, Nicole Lesko, Leif Karlsson, Lucía Peña‐Pérez, Ann Båvner, Virpi Töhönen, Anna Lindstrand, Tommy Stödberg, Anna Wedell   +10 more
wiley   +1 more source

Inherited non‐syndromic polydactyly in a Berber and Arabian‐Berber horse family

Equine Veterinary Journal, EarlyView.
Abstract Background Supernumerary digits, or polydactyly, have been described in various species including humans, wild and domestic animals. In horses, it represents the most common congenital limb malformation, which has only been described in isolated cases or nuclear families. Molecular aetiology has not been reported.
Ella Baville, Bianca Carstanjen, Aurélie Thomas‐Cancian, Anne Calgaro, Nathale Bonnet, Laurent Tiret, Vincent Gache, Marie Abitbol   +7 more
wiley   +1 more source

A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation. [PDF]

Curr Biol
Parnell EJ, Jenson EE, Miller MP.
europepmc   +1 more source

Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin–antitoxin systems

The FEBS Journal, EarlyView.
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon, Noëlla Germain‐Amiot, Charlotte Oriol, Astrid Rouillon, Yoann Augagneur, Stéphane Dréano, Irène Nicolas, Alexandre Chenal, Arnaud Bondon, Soizic Chevance, Marie‐Laure Pinel‐Marie   +10 more
wiley   +1 more source

Mutations in tyrosyl-DNA phosphodiesterase 2 suppress top-2 induced chromosome segregation defects during Caenorhabditis elegans spermatogenesis. [PDF]

J Biol Chem
Kwah JK, Bhandari N, Rourke C, Gassaway G, Jaramillo-Lambert A.   +4 more
europepmc   +1 more source

Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos. [PDF]

Nat Commun
Kiyomitsu A, Nishimura T, Hwang SJ, Ansai S, Kanemaki MT, Tanaka M, Kiyomitsu T.   +6 more
europepmc   +1 more source

Toxoplasma gondii modulates the host cell cycle, chromosome segregation, and cytokinesis irrespective of cell type or species origin. [PDF]

Parasit Vectors
Rojas-Baron L, Senk K, Hermosilla C, Taubert A, Velásquez ZD.   +4 more
europepmc   +1 more source