Results 41 to 50 of about 1,037,337 (302)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mechanisms for Chromosome Segregation in Bacteria

Frontiers in Microbiology, 2021
The process of DNA segregation, the redistribution of newly replicated genomic material to daughter cells, is a crucial step in the life cycle of all living systems.
Christos Gogou, Aleksandre Japaridze, Cees Dekker   +2 more
doaj   +1 more source

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops [PDF]

, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Petit M-A, El Karoui, Meriem, El Karoui, M, Bourgait, Isabelle, Gendrault-Jacquemard, A, Sourivong, Frédéric, Gendrault, Annie, Gendrault-Jacquemard, Gendrault-Jacquemard A, Chiapello H, Chiapello, H, Sourivong F, Bourgait I, Heuclin G, El Karoui M, El Karoui, Meriem, M., Heuclin, G, Petit, M-A, Bourgait, I, Heuclin, Gaëlle, Chiapello, Helene, Petit, Marie Agnès, Petit, Marie Agnes, M. A., Sourivong, F, Gendrault, Annie   +23 more
core   +1 more source

Bacterial artificial chromosomes improve recombinant protein production in mammalian cells

BMC Biotechnology, 2009
Background The development of appropriate expression vectors for large scale protein production constitutes a critical step in recombinant protein production.
Bauer Anton, Eferl Robert, Musteanu Monica, Blaas Leander, Casanova Emilio   +4 more
doaj   +1 more source

Structure of metaphase chromosomes: a role for effects of macromolecular crowding. [PDF]

PLoS ONE, 2012
In metaphase chromosomes, chromatin is compacted to a concentration of several hundred mg/ml by mechanisms which remain elusive. Effects mediated by the ionic environment are considered most frequently because mono- and di-valent cations cause ...
Ronald Hancock
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The B chromosomes of the African cichlid fish Haplochromis obliquidens harbour 18S rRNA gene copies

BMC Genetics, 2010
Background Diverse plant and animal species have B chromosomes, also known as accessory, extra or supernumerary chromosomes. Despite being widely distributed among different taxa, the genomic nature and genetic behavior of B chromosomes are still poorly ...
Martins Cesar, Ferreira Irani A, Poletto Andréia B   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes [PDF]

, 2005
Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional implications during development and cell differentiation.
Kreth Gregor, Michael R Speicher, Bolzer Andreas, Cremer Christoph, Kreth, G., Andreas Bolzer (83), Cremer, Christoph, Eils, R., Christoph Cremer, Christoph Cremer (91), Fauth Christine, Irina Solovei, Solovei, Irina, Daniela Koehler, Gregor Kreth (84), Eils, Roland, Gregor Kreth, Kaan Saracoglu, Bolzer, Andreas, Koehler Daniela, Irina Solovei (85), Fauth, C., Thomas Cremer (93), Bolzer, A., Speicher, Michael R., Müller Stefan, Solovei Irina, Müller, Stefan, Saracoglu, Kaan, Stefan Müller, Fauth, Christine, Roland Eils (90), Kreth, Gregor, Cremer Thomas, Koehler, D., Stefan Müller (89), Michael R Speicher (27551), Thomas Cremer, Solovei, I., Roland Eils, Müller, S., Cremer, C., Koehler, Daniela, Speicher, M.R., Eils Roland, Speicher Michael R, Cremer, Thomas, Andreas Bolzer, Daniela Koehler (86), Christine Fauth (88), Cremer, T., Saracoglu Kaan, Christine Fauth, Kaan Saracoglu (87), Saracoglu, K.   +54 more
core   +1 more source

Physical models of bacterial chromosomes [PDF]

, 2023
The interplay between bacterial chromosome organization and functions such as transcription and replication can be studied in increasing detail using novel experimental techniques.
Harju, Janni, Broedersz, Chase P.
core   +1 more source