Results 41 to 50 of about 74,687 (303)

Identification of DNA motifs implicated in maintenance of bacterial core genomes by predictive modeling [PDF]

, 2007
Bacterial biodiversity at the species level, in terms of gene acquisition or loss, is so immense that it raises the question of how essential chromosomal regions are spared from uncontrolled rearrangements.
El Karoui, Meriem, Robin Stéphane, Schbath, Sophie, Sophie Schbath, Meriem El Karoui, Robin, Stéphane, El Karoui Meriem, Christelle Hennequet-Antier, Hélène Chiapello, David Halpern, Chiapello, Hélène, Gruss Alexandra, Halpern, David, Stéphane Robin, Schbath Sophie, Hennequet-Antier Christelle, Hennequet-Antier, Christelle, Halpern David, Alexandra Gruss, Gruss, Alexandra, Chiapello Hélène   +20 more
core   +1 more source

Optically mapping multiple bacterial genomes simultaneously in a single run. [PDF]

PLoS ONE, 2011
Optical mapping of bacterial chromosomes provides an unambiguous low-resolution sequence scaffold of the entire chromosome. In comparison to some techniques, such as pulse field gel electrophoresis, cost and throughput limit the application of this ...
Matthew C Riley, James Eric Lee, Emil Lesho, Benjamin C Kirkup   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Bacterial artificial chromosomes improve recombinant protein production in mammalian cells

BMC Biotechnology, 2009
Background The development of appropriate expression vectors for large scale protein production constitutes a critical step in recombinant protein production.
Bauer Anton, Eferl Robert, Musteanu Monica, Blaas Leander, Casanova Emilio   +4 more
doaj   +1 more source

Structure of metaphase chromosomes: a role for effects of macromolecular crowding. [PDF]

PLoS ONE, 2012
In metaphase chromosomes, chromatin is compacted to a concentration of several hundred mg/ml by mechanisms which remain elusive. Effects mediated by the ionic environment are considered most frequently because mono- and di-valent cations cause ...
Ronald Hancock
doaj   +1 more source

Bacterial Chromosome Dynamics

Science, 2003
Bacterial chromosomes are highly compacted structures and share many properties with their eukaryote counterparts, despite not being organized into chromatin or being contained within a cell nucleus. Proteins conserved across all branches of life act in chromosome organization, and common mechanisms maintain genome integrity and ensure faithful ...
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Spatial Chromosome Organization and Adaptation of Escherichia coli under Heat Stress

Microorganisms
The spatial organization of bacterial chromosomes is crucial for cellular functions. It remains unclear how bacterial chromosomes adapt to high-temperature stress.
Xu-Ting Wang, Bin-Guang Ma
doaj   +1 more source

The B chromosomes of the African cichlid fish Haplochromis obliquidens harbour 18S rRNA gene copies

BMC Genetics, 2010
Background Diverse plant and animal species have B chromosomes, also known as accessory, extra or supernumerary chromosomes. Despite being widely distributed among different taxa, the genomic nature and genetic behavior of B chromosomes are still poorly ...
Martins Cesar, Ferreira Irani A, Poletto Andréia B   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source